258584

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5218811..5219436 Replicon chromosome
Accession NZ_CP104603
Organism Klebsiella pneumoniae strain AHM8C161BI

Toxin (Protein)


Gene name vapC Uniprot ID A0A378FVD4
Locus tag N5862_RS25725 Protein ID WP_019705794.1
Coordinates 5218811..5219194 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag N5862_RS25730 Protein ID WP_004150355.1
Coordinates 5219194..5219436 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5862_RS25710 (5216177) 5216177..5217079 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
N5862_RS25715 (5217076) 5217076..5217711 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
N5862_RS25720 (5217708) 5217708..5218637 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
N5862_RS25725 (5218811) 5218811..5219194 - 384 WP_019705794.1 type II toxin-antitoxin system VapC family toxin Toxin
N5862_RS25730 (5219194) 5219194..5219436 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
N5862_RS25735 (5219641) 5219641..5220558 + 918 WP_004146235.1 alpha/beta hydrolase -
N5862_RS25740 (5220573) 5220573..5221514 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
N5862_RS25745 (5221559) 5221559..5221996 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
N5862_RS25750 (5221993) 5221993..5222853 - 861 WP_004146232.1 virulence factor BrkB family protein -
N5862_RS25755 (5222847) 5222847..5223446 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14358.57 Da        Isoelectric Point: 6.8806

>T258584 WP_019705794.1 NZ_CP104603:c5219194-5218811 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGHREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT258584 WP_004150355.1 NZ_CP104603:c5219436-5219194 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378FVD4

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References