Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4721188..4721704 Replicon chromosome
Accession NZ_CP104603
Organism Klebsiella pneumoniae strain AHM8C161BI

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag N5862_RS23365 Protein ID WP_004178374.1
Coordinates 4721188..4721472 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag N5862_RS23370 Protein ID WP_002886901.1
Coordinates 4721462..4721704 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5862_RS23340 (4716583) 4716583..4716846 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
N5862_RS23345 (4716976) 4716976..4717149 + 174 WP_032412860.1 hypothetical protein -
N5862_RS23350 (4717152) 4717152..4717895 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
N5862_RS23355 (4718252) 4718252..4720390 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
N5862_RS23360 (4720720) 4720720..4721184 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N5862_RS23365 (4721188) 4721188..4721472 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5862_RS23370 (4721462) 4721462..4721704 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N5862_RS23375 (4721782) 4721782..4723692 - 1911 WP_004152270.1 PRD domain-containing protein -
N5862_RS23380 (4723715) 4723715..4724869 - 1155 WP_002886900.1 lactonase family protein -
N5862_RS23385 (4724936) 4724936..4725676 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T258582 WP_004178374.1 NZ_CP104603:c4721472-4721188 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT258582 WP_002886901.1 NZ_CP104603:c4721704-4721462 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References