258580

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4010353..4010972 Replicon chromosome
Accession NZ_CP104603
Organism Klebsiella pneumoniae strain AHM8C161BI

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag N5862_RS20005 Protein ID WP_002892050.1
Coordinates 4010754..4010972 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag N5862_RS20000 Protein ID WP_002892066.1
Coordinates 4010353..4010727 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5862_RS19990 (4005505) 4005505..4006698 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N5862_RS19995 (4006721) 4006721..4009867 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
N5862_RS20000 (4010353) 4010353..4010727 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
N5862_RS20005 (4010754) 4010754..4010972 + 219 WP_002892050.1 HHA domain-containing protein Toxin
N5862_RS20010 (4011135) 4011135..4011701 + 567 WP_002892030.1 maltose O-acetyltransferase -
N5862_RS20015 (4011673) 4011673..4011813 - 141 WP_004147370.1 hypothetical protein -
N5862_RS20020 (4011834) 4011834..4012304 + 471 WP_002892026.1 YlaC family protein -
N5862_RS20025 (4012279) 4012279..4013730 - 1452 WP_064151794.1 PLP-dependent aminotransferase family protein -
N5862_RS20030 (4013831) 4013831..4014529 + 699 WP_002892021.1 GNAT family protein -
N5862_RS20035 (4014526) 4014526..4014666 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
N5862_RS20040 (4014666) 4014666..4014929 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T258580 WP_002892050.1 NZ_CP104603:4010754-4010972 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T258580 NZ_CP104603:4010754-4010972 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT258580 WP_002892066.1 NZ_CP104603:4010353-4010727 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT258580 NZ_CP104603:4010353-4010727 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References