Detailed information of TA system TA025858

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/Fic-DUF4065
• Location: 739408..740438
• Replicon: chromosome
• Accession: NC_016783
• Organism: Corynebacterium diphtheriae INCA 402

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: CDB402_RS03600
• Protein ID: WP_014303124.1
• Coordinates: 739408..739860 (-)
• Length: 151 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: CDB402_RS03605
• Protein ID: WP_014303125.1
• Coordinates: 739872..740438 (-)
• Length: 189 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDB402_RS03585	736066..736920	+	855	WP_014303121.1	hypothetical protein	-
CDB402_RS03590	736913..737821	-	909	WP_014303122.1	DUF1906 domain-containing protein	-
CDB402_RS03595	737950..739149	-	1200	WP_014303123.1	cation:proton antiporter	-
CDB402_RS03600	739408..739860	-	453	WP_014303124.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
CDB402_RS03605	739872..740438	-	567	WP_014303125.1	SocA family protein	Antitoxin
CDB402_RS03610	740706..740978	-	273	WP_014303126.1	hypothetical protein	-
CDB402_RS03620	741802..742077	+	276	WP_014303127.1	hypothetical protein	-
CDB402_RS03625	742084..742836	+	753	WP_014303128.1	precorrin-6A synthase (deacetylating)	-
CDB402_RS03630	742855..743112	-	258	WP_010934589.1	mycoredoxin	-
CDB402_RS03635	743133..743636	-	504	WP_014303129.1	dihydrofolate reductase	-
CDB402_RS03640	743636..744448	-	813	WP_014303130.1	thymidylate synthase	-
CDB402_RS03645	744542..745300	-	759	WP_010934592.1	3'(2'),5'-bisphosphate nucleotidase CysQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	739408..750153	10745

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (45-127)

Antitoxin

• Antitoxin SocA-like, Panacea domain (23-116)

Sequences

Toxin

Protein

• Length: 151 a.a.
• Molecular weight: 16477.60 Da
• Isoelectric Point: 7.7987

>T25858 WP_014303124.1 NC_016783:c739860-739408 [Corynebacterium diphtheriae INCA 402]
VSGNSGASPQDMVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLF
KLANGHYFQDGNKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD

Nucleotide

• Length: 453 bp

>T25858 NC_016783:c739860-739408 [Corynebacterium diphtheriae INCA 402]
GTGTCGGGAAATAGCGGGGCATCACCGCAGGACATGGTGAACAAGTTGGTCTACTTATCCTGCACCTTAAATCAGGAGTG
CGGGAAGCGAACAGGTCCTCACAGAGAACCTGAACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGTGGGCTAGAGGGCG
CGATCGCTTCAGTATTTCAATCGTCGTTTGGCGTCTTGCTGTACCCGACCATCTACGACCAAGCGGCCGCACTCCTGTTC
AAGCTGGCAAACGGGCATTACTTCCAAGACGGAAACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAA
TAACGTTCACGTCAGTCCCCCTCGGTCTGATGACGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAAG
AAAACGGGATAGCGTTCGTTAGACAAAAGCTTTTGGACTGGACCGTAGACTGA

Antitoxin

Protein

• Length: 189 a.a.
• Molecular weight: 20990.48 Da
• Isoelectric Point: 4.7265

>AT25858 WP_014303125.1 NC_016783:c740438-739872 [Corynebacterium diphtheriae INCA 402]
MISILHVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPSHLP
STALDSLEQAADDVATENAETLRLLAFI

Nucleotide

• Length: 567 bp

>AT25858 NC_016783:c740438-739872 [Corynebacterium diphtheriae INCA 402]
ATGATCAGCATCCTCCATGTTGCAGCGCGTGTACTTGAGCTGCACCCTTCCTGCGACAAGATGAAGCTGTACAAACTGTG
TTACTTCTCCCAGGGGTGGCACTTGGCATGGACAGGTCGTCCACTATTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACCTTGCGTCAGGCTAGCGAGCTTCGTGCCGATGATGACCGTCGAGTGACCCAAATTTGGAGCGGGGAC
AGTTCTCAACTCACCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGAGATCTTGGGTCTTTTCACCT
GTCCGATTTGAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCGACCTTCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTTCACACCTGCCT
TCCACGGCACTTGATTCTCTCGAGCAGGCAGCCGATGACGTTGCTACTGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG