Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 801641..802298 Replicon chromosome
Accession NZ_CP104603
Organism Klebsiella pneumoniae strain AHM8C161BI

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag N5862_RS03980 Protein ID WP_002916310.1
Coordinates 801888..802298 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag N5862_RS03975 Protein ID WP_002916312.1
Coordinates 801641..801907 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5862_RS03950 (796797) 796797..798230 - 1434 WP_064152027.1 6-phospho-beta-glucosidase -
N5862_RS03955 (798349) 798349..799077 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
N5862_RS03960 (799127) 799127..799438 + 312 WP_064152028.1 N(4)-acetylcytidine aminohydrolase -
N5862_RS03965 (799602) 799602..800261 + 660 WP_002916317.1 hemolysin III family protein -
N5862_RS03970 (800412) 800412..801395 - 984 WP_064152029.1 tRNA-modifying protein YgfZ -
N5862_RS03975 (801641) 801641..801907 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
N5862_RS03980 (801888) 801888..802298 + 411 WP_002916310.1 protein YgfX Toxin
N5862_RS03985 (802305) 802305..802826 - 522 WP_004144730.1 flavodoxin FldB -
N5862_RS03990 (802927) 802927..803823 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
N5862_RS03995 (803846) 803846..804559 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N5862_RS04000 (804565) 804565..806298 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T258574 WP_002916310.1 NZ_CP104603:801888-802298 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT258574 WP_002916312.1 NZ_CP104603:801641-801907 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References