Detailed information of TA system TA025857

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 117156..117639
• Replicon: chromosome
• Accession: NC_016783
• Organism: Corynebacterium diphtheriae INCA 402

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A806GHY4
• Locus tag: CDB402_RS00605
• Protein ID: WP_014302726.1
• Coordinates: 117376..117639 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: CDB402_RS11580
• Protein ID: WP_193345912.1
• Coordinates: 117156..117392 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDB402_RS11570	112390..112647	+	258	Protein_108	hypothetical protein	-
CDB402_RS11575	112696..112929	+	234	WP_080563667.1	hypothetical protein	-
CDB402_RS00575	113507..113893	+	387	WP_014301198.1	hypothetical protein	-
CDB402_RS00580	113901..114263	+	363	WP_014302722.1	hypothetical protein	-
CDB402_RS12165	114321..115758	+	1438	Protein_112	IS30 family transposase	-
CDB402_RS00595	115970..116653	-	684	WP_014302723.1	hypothetical protein	-
CDB402_RS11580	117156..117392	+	237	WP_193345912.1	ribbon-helix-helix domain-containing protein	Antitoxin
CDB402_RS00605	117376..117639	+	264	WP_014302726.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CDB402_RS00610	117765..118058	+	294	WP_014302727.1	RNA-binding S4 domain-containing protein	-
CDB402_RS00615	118058..118882	+	825	WP_014301205.1	VOC family protein	-
CDB402_RS00620	118888..119193	+	306	WP_003850125.1	MGMT family protein	-
CDB402_RS00625	119203..120123	-	921	WP_014301206.1	alpha/beta hydrolase	-
CDB402_RS00630	120263..120889	+	627	WP_014302728.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• Predicted DNA-binding protein, ribbon-helix-helix domain (7-42)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9911.45 Da
• Isoelectric Point: 10.9201

>T25857 WP_014302726.1 NC_016783:117376-117639 [Corynebacterium diphtheriae INCA 402]
VAWEISFSPRAVKSFKKLDTGEQRRVSKFLREVGALEDPRLRGKALTANKSGLWRWRVGDYRIIADIVDARVVVVVVDVG
HRSKAYD

Nucleotide

• Length: 264 bp

>T25857 NC_016783:117376-117639 [Corynebacterium diphtheriae INCA 402]
GTGGCTTGGGAGATTAGTTTTTCTCCTCGGGCGGTGAAGTCGTTTAAGAAGCTCGATACGGGTGAGCAGCGGAGGGTGAG
TAAGTTTCTGCGGGAGGTTGGCGCCCTTGAGGACCCGAGGTTACGAGGTAAGGCATTAACAGCCAATAAGTCGGGTTTGT
GGCGCTGGCGTGTGGGGGACTATCGGATTATTGCTGACATTGTGGACGCGCGTGTTGTCGTCGTTGTGGTTGACGTTGGG
CACCGCTCGAAGGCCTACGACTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8939.07 Da
• Isoelectric Point: 4.8604

>AT25857 WP_193345912.1 NC_016783:117156-117392 [Corynebacterium diphtheriae INCA 402]
MSGSVISLRIDDEQKRRLDELSRRTGRPCSFYLREALSVHLADLEYVYRLEEEAAQVRRGELGTVPLSQLERECGLGD

Nucleotide

• Length: 237 bp

>AT25857 NC_016783:117156-117392 [Corynebacterium diphtheriae INCA 402]
ATGAGTGGTTCGGTGATTAGCTTGCGTATCGATGACGAGCAGAAGCGGCGTTTGGATGAGCTGTCGCGACGTACGGGGCG
GCCGTGTTCGTTTTATCTTCGGGAAGCGTTGAGTGTACATCTGGCTGATCTGGAGTATGTGTATCGCTTGGAGGAGGAGG
CTGCTCAGGTTCGTCGCGGGGAGTTGGGAACTGTGCCGTTGAGTCAGCTGGAGCGCGAGTGTGGCTTGGGAGATTAG

Structures

Toxin

• AlphaFold DB: A0A806GHY4