Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4372553..4373184 Replicon chromosome
Accession NZ_CP104598
Organism Escherichia coli strain AHM8C160RI

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag N5861_RS21170 Protein ID WP_001259385.1
Coordinates 4372909..4373184 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag N5861_RS21165 Protein ID WP_000593555.1
Coordinates 4372553..4372912 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5861_RS21140 (4368685) 4368685..4369629 + 945 WP_000947062.1 nickel ABC transporter permease subunit NikB -
N5861_RS21145 (4369626) 4369626..4370459 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
N5861_RS21150 (4370459) 4370459..4371223 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
N5861_RS21155 (4371220) 4371220..4372026 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
N5861_RS21160 (4372032) 4372032..4372433 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
N5861_RS21165 (4372553) 4372553..4372912 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N5861_RS21170 (4372909) 4372909..4373184 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
N5861_RS21175 (4373257) 4373257..4374381 - 1125 WP_001314210.1 ABC transporter permease -
N5861_RS21180 (4374381) 4374381..4377116 - 2736 WP_085008733.1 ribosome-associated ATPase/putative transporter RbbA -
N5861_RS21185 (4377113) 4377113..4378180 - 1068 WP_097702179.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T258567 WP_001259385.1 NZ_CP104598:c4373184-4372909 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT258567 WP_000593555.1 NZ_CP104598:c4372912-4372553 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References