Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4351046..4351846 Replicon chromosome
Accession NZ_CP104598
Organism Escherichia coli strain AHM8C160RI

Toxin (Protein)


Gene name ataT Uniprot ID U9Y257
Locus tag N5861_RS21045 Protein ID WP_000342447.1
Coordinates 4351046..4351573 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID U9Y285
Locus tag N5861_RS21050 Protein ID WP_001277109.1
Coordinates 4351580..4351846 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5861_RS21020 (4346121) 4346121..4346888 - 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
N5861_RS21025 (4346885) 4346885..4348162 - 1278 WP_000803782.1 branched chain amino acid ABC transporter permease LivM -
N5861_RS21030 (4348159) 4348159..4349085 - 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
N5861_RS21035 (4349133) 4349133..4350242 - 1110 WP_001301528.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
N5861_RS21040 (4350666) 4350666..4351049 + 384 WP_000778795.1 aspartate 1-decarboxylase autocleavage activator PanM -
N5861_RS21045 (4351046) 4351046..4351573 - 528 WP_000342447.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
N5861_RS21050 (4351580) 4351580..4351846 - 267 WP_001277109.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
N5861_RS21055 (4351996) 4351996..4353099 - 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
N5861_RS21060 (4353370) 4353370..4354224 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
N5861_RS21065 (4354469) 4354469..4355527 - 1059 WP_001042003.1 permease-like cell division protein FtsX -
N5861_RS21070 (4355520) 4355520..4356188 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.63 Da        Isoelectric Point: 7.0284

>T258566 WP_000342447.1 NZ_CP104598:c4351573-4351046 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDHSIQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYKSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9938.37 Da        Isoelectric Point: 10.0863

>AT258566 WP_001277109.1 NZ_CP104598:c4351846-4351580 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AVKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LUM2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LUN0

References