Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | rnlAB/RnlA-RnlB |
Location | 3392340..3393765 | Replicon | chromosome |
Accession | NZ_CP104598 | ||
Organism | Escherichia coli strain AHM8C160RI |
Toxin (Protein)
Gene name | rnlA | Uniprot ID | A0A1X9TDS5 |
Locus tag | N5861_RS16405 | Protein ID | WP_001730411.1 |
Coordinates | 3392695..3393765 (-) | Length | 357 a.a. |
Antitoxin (Protein)
Gene name | rnlB | Uniprot ID | E6BSF0 |
Locus tag | N5861_RS16400 | Protein ID | WP_000461705.1 |
Coordinates | 3392340..3392702 (-) | Length | 121 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N5861_RS16365 (3387472) | 3387472..3389133 | + | 1662 | WP_000880916.1 | DNA repair protein RecN | - |
N5861_RS16370 (3389282) | 3389282..3389623 | + | 342 | WP_001203437.1 | outer membrane protein assembly factor BamE | - |
N5861_RS16375 (3389685) | 3389685..3389975 | - | 291 | WP_001117838.1 | RnfH family protein | - |
N5861_RS16380 (3389965) | 3389965..3390402 | - | 438 | WP_001341638.1 | type II toxin-antitoxin system toxin RatA | - |
N5861_RS16385 (3390573) | 3390573..3391055 | + | 483 | WP_000162574.1 | SsrA-binding protein SmpB | - |
N5861_RS16395 (3391933) | 3391933..3392202 | + | 270 | WP_000429347.1 | hypothetical protein | - |
N5861_RS16400 (3392340) | 3392340..3392702 | - | 363 | WP_000461705.1 | type II toxin-antitoxin system RnlB family antitoxin | Antitoxin |
N5861_RS16405 (3392695) | 3392695..3393765 | - | 1071 | WP_001730411.1 | type II toxin-antitoxin system RnlA family toxin | Toxin |
N5861_RS16410 (3393900) | 3393900..3394096 | - | 197 | Protein_3207 | recombinase family protein | - |
N5861_RS16420 (3395427) | 3395427..3396737 | + | 1311 | Protein_3209 | alpha amylase C-terminal domain-containing protein | - |
N5861_RS16425 (3397075) | 3397075..3398052 | + | 978 | WP_032222549.1 | glutarate dioxygenase GlaH | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 357 a.a. Molecular weight: 40463.36 Da Isoelectric Point: 6.8748
>T258559 WP_001730411.1 NZ_CP104598:c3393765-3392695 [Escherichia coli]
MTVRNYTNLNLDRTTIEATSRAFIENKNYSVHSIGPMPGARAGLRVVFAKPGEALATVNIFYNNGGTSTVQYQTGANHNL
GKELADDLYETINPAEFEQVNMVLQGFVEANVLSVLQLSAEQPHIQFYEYLRNTHTTVWKIHSPEFQDELTVSLHHRNGT
LQIQGRPLSCYRVFIFNLSELLDLQGLEKVLIRQDDGKAYIVQKEVARSHLECEMGDAYPLLHKNVEKLLVSGLCVKLAA
PDLPDYCMLLYPELRSVEGVLKSTMYRYGMPITQDGFGRYFDKIGSEFILKQQFGCNLSSAKVKTINDAYTFFNRERHGL
FHMEIVVDTSRMVSDMARLMTKARQAWGIIKDLYIV
MTVRNYTNLNLDRTTIEATSRAFIENKNYSVHSIGPMPGARAGLRVVFAKPGEALATVNIFYNNGGTSTVQYQTGANHNL
GKELADDLYETINPAEFEQVNMVLQGFVEANVLSVLQLSAEQPHIQFYEYLRNTHTTVWKIHSPEFQDELTVSLHHRNGT
LQIQGRPLSCYRVFIFNLSELLDLQGLEKVLIRQDDGKAYIVQKEVARSHLECEMGDAYPLLHKNVEKLLVSGLCVKLAA
PDLPDYCMLLYPELRSVEGVLKSTMYRYGMPITQDGFGRYFDKIGSEFILKQQFGCNLSSAKVKTINDAYTFFNRERHGL
FHMEIVVDTSRMVSDMARLMTKARQAWGIIKDLYIV
Download Length: 1071 bp
Antitoxin
Download Length: 121 a.a. Molecular weight: 13304.23 Da Isoelectric Point: 4.2386
>AT258559 WP_000461705.1 NZ_CP104598:c3392702-3392340 [Escherichia coli]
MFEITGVNVSGALIAVVMATGYENPLTSVHEIEKRLSVILGNSQATGEVLFDLLCSNGPEWNRFVSLEIRCGSILLDTAK
IVDEQEIPAQILRHQRDVLRNHPEYVEDSVLTPDDVLCIL
MFEITGVNVSGALIAVVMATGYENPLTSVHEIEKRLSVILGNSQATGEVLFDLLCSNGPEWNRFVSLEIRCGSILLDTAK
IVDEQEIPAQILRHQRDVLRNHPEYVEDSVLTPDDVLCIL
Download Length: 363 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1X9TDS5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1X9TDS3 |