Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2169545..2171133 | Replicon | chromosome |
Accession | NZ_CP104598 | ||
Organism | Escherichia coli strain AHM8C160RI |
Toxin (Protein)
Gene name | hipA | Uniprot ID | - |
Locus tag | N5861_RS10360 | Protein ID | WP_033815613.1 |
Coordinates | 2169545..2170867 (-) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | N5861_RS10365 | Protein ID | WP_250308169.1 |
Coordinates | 2170867..2171133 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N5861_RS10345 (2166937) | 2166937..2167647 | - | 711 | WP_001195166.1 | fimbria/pilus periplasmic chaperone | - |
N5861_RS10350 (2168008) | 2168008..2168571 | - | 564 | WP_001296758.1 | type 1 fimbrial major subunit FimA | - |
N5861_RS10355 (2169005) | 2169005..2169280 | - | 276 | Protein_2020 | AraC family transcriptional regulator | - |
N5861_RS10360 (2169545) | 2169545..2170867 | - | 1323 | WP_033815613.1 | type II toxin-antitoxin system serine/threonine protein kinase toxin HipA | Toxin |
N5861_RS10365 (2170867) | 2170867..2171133 | - | 267 | WP_250308169.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
N5861_RS10370 (2171222) | 2171222..2174156 | - | 2935 | Protein_2023 | ESPR-type extended signal peptide-containing protein | - |
N5861_RS10375 (2174687) | 2174687..2175256 | - | 570 | Protein_2024 | FGGY-family carbohydrate kinase | - |
N5861_RS10380 (2175255) | 2175255..2175515 | + | 261 | Protein_2025 | autoinducer 2 ABC transporter substrate-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49334.97 Da Isoelectric Point: 8.5823
>T258553 WP_033815613.1 NZ_CP104598:c2170867-2169545 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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