Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3592913..3593750 Replicon chromosome
Accession NZ_CP104595
Organism Escherichia coli strain EC9952

Toxin (Protein)


Gene name itaT Uniprot ID -
Locus tag N5B57_RS17540 Protein ID WP_063120031.1
Coordinates 3593208..3593750 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag N5B57_RS17535 Protein ID WP_001297137.1
Coordinates 3592913..3593224 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5B57_RS17510 (3587933) 3587933..3588880 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
N5B57_RS17515 (3588902) 3588902..3590893 + 1992 WP_094312410.1 cytochrome o ubiquinol oxidase subunit I -
N5B57_RS17520 (3590883) 3590883..3591497 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
N5B57_RS17525 (3591497) 3591497..3591826 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
N5B57_RS17530 (3591838) 3591838..3592728 + 891 WP_000971336.1 heme o synthase -
N5B57_RS17535 (3592913) 3592913..3593224 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
N5B57_RS17540 (3593208) 3593208..3593750 + 543 WP_063120031.1 GNAT family N-acetyltransferase Toxin
N5B57_RS17545 (3593806) 3593806..3594741 - 936 WP_272471720.1 tetratricopeptide repeat protein -
N5B57_RS17550 (3595148) 3595148..3596512 + 1365 WP_001000978.1 MFS transporter -
N5B57_RS17555 (3596640) 3596640..3597131 - 492 WP_001138904.1 nucleotide binding protein YajQ -
N5B57_RS17560 (3597299) 3597299..3598210 + 912 WP_000705853.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19705.88 Da        Isoelectric Point: 8.0330

>T258534 WP_063120031.1 NZ_CP104595:3593208-3593750 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVAGKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT258534 WP_001297137.1 NZ_CP104595:3592913-3593224 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References