Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1356596..1357221 Replicon chromosome
Accession NZ_CP104595
Organism Escherichia coli strain EC9952

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N5B57_RS06640 Protein ID WP_000911330.1
Coordinates 1356823..1357221 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag N5B57_RS06635 Protein ID WP_000450524.1
Coordinates 1356596..1356823 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5B57_RS06610 (1352399) 1352399..1352869 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
N5B57_RS06615 (1352869) 1352869..1353441 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
N5B57_RS06620 (1353587) 1353587..1354465 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
N5B57_RS06625 (1354482) 1354482..1355516 + 1035 WP_001330579.1 outer membrane protein assembly factor BamC -
N5B57_RS06630 (1355729) 1355729..1356442 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
N5B57_RS06635 (1356596) 1356596..1356823 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
N5B57_RS06640 (1356823) 1356823..1357221 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
N5B57_RS06645 (1357368) 1357368..1358231 + 864 WP_001267498.1 neutral zinc metallopeptidase -
N5B57_RS06650 (1358246) 1358246..1360261 + 2016 WP_047086710.1 tRNA cytosine(34) acetyltransferase TmcA -
N5B57_RS06655 (1360335) 1360335..1361033 + 699 WP_000679812.1 esterase -
N5B57_RS06660 (1361143) 1361143..1361343 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T258525 WP_000911330.1 NZ_CP104595:1356823-1357221 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT258525 WP_000450524.1 NZ_CP104595:1356596-1356823 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References