Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 50170..51086 | Replicon | plasmid pWTJH36 |
| Accession | NZ_CP104591 | ||
| Organism | Pseudomonas aeruginosa strain WTJH36 | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | A0A212BIN6 |
| Locus tag | N5878_RS33555 | Protein ID | WP_021018402.1 |
| Coordinates | 50562..51086 (+) | Length | 175 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | A0A2I0C738 |
| Locus tag | N5878_RS33550 | Protein ID | WP_010792483.1 |
| Coordinates | 50170..50565 (+) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N5878_RS33535 (N5878_33535) | 46193..46717 | - | 525 | WP_010792479.1 | hypothetical protein | - |
| N5878_RS33540 (N5878_33540) | 47596..47877 | - | 282 | WP_010792481.1 | hypothetical protein | - |
| N5878_RS33545 (N5878_33545) | 48026..49960 | + | 1935 | WP_021018401.1 | hypothetical protein | - |
| N5878_RS33550 (N5878_33550) | 50170..50565 | + | 396 | WP_010792483.1 | hypothetical protein | Antitoxin |
| N5878_RS33555 (N5878_33555) | 50562..51086 | + | 525 | WP_021018402.1 | RES family NAD+ phosphorylase | Toxin |
| N5878_RS33560 (N5878_33560) | 51132..52382 | - | 1251 | WP_010792484.1 | TerD family protein | - |
| N5878_RS33565 (N5878_33565) | 52579..53634 | - | 1056 | WP_021018403.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
| N5878_RS33570 (N5878_33570) | 54012..54203 | + | 192 | WP_010792486.1 | hypothetical protein | - |
| N5878_RS33575 (N5878_33575) | 54625..55770 | - | 1146 | WP_021018404.1 | glycerate kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaVIM-24 / blaOXA-101 / ant(3'')-Ia / qacE / sul1 / aph(3'')-Ib / aph(6)-Id | - | 1..462066 | 462066 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 175 a.a. Molecular weight: 19011.47 Da Isoelectric Point: 4.4540
>T258518 WP_021018402.1 NZ_CP104591:50562-51086 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQGSAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIVGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQGSAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIVGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
Download Length: 525 bp
Antitoxin
Download Length: 132 a.a. Molecular weight: 14810.93 Da Isoelectric Point: 7.2048
>AT258518 WP_010792483.1 NZ_CP104591:50170-50565 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
Download Length: 396 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A212BIN6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I0C738 |