258517

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 6926171..6927213 Replicon chromosome
Accession NZ_CP104590
Organism Pseudomonas aeruginosa strain WTJH36

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag N5878_RS32330 Protein ID WP_003153636.1
Coordinates 6926638..6927213 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag N5878_RS32325 Protein ID WP_003050245.1
Coordinates 6926171..6926641 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5878_RS32290 (N5878_32290) 6921563..6922981 - 1419 WP_006226029.1 TIGR03752 family integrating conjugative element protein -
N5878_RS32295 (N5878_32295) 6922971..6923882 - 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
N5878_RS32300 (N5878_32300) 6923879..6924571 - 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
N5878_RS32305 (N5878_32305) 6924568..6924966 - 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
N5878_RS32310 (N5878_32310) 6924978..6925337 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
N5878_RS32315 (N5878_32315) 6925354..6925587 - 234 WP_006226027.1 TIGR03758 family integrating conjugative element protein -
N5878_RS32320 (N5878_32320) 6925584..6925967 - 384 WP_260889984.1 RAQPRD family integrative conjugative element protein -
N5878_RS32325 (N5878_32325) 6926171..6926641 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
N5878_RS32330 (N5878_32330) 6926638..6927213 + 576 WP_003153636.1 PIN domain-containing protein Toxin
N5878_RS32335 (N5878_32335) 6927231..6928145 + 915 WP_016852809.1 AAA family ATPase -
N5878_RS32340 (N5878_32340) 6928142..6928612 + 471 WP_003090160.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
N5878_RS32345 (N5878_32345) 6928609..6929109 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
N5878_RS32350 (N5878_32350) 6929109..6930011 + 903 WP_003090158.1 CBASS oligonucleotide cyclase -
N5878_RS32355 (N5878_32355) 6930050..6930775 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 6851596..6973328 121732


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T258517 WP_003153636.1 NZ_CP104590:6926638-6927213 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT258517 WP_003050245.1 NZ_CP104590:6926171-6926641 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References