Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2345097..2346355 Replicon chromosome
Accession NZ_CP104590
Organism Pseudomonas aeruginosa strain WTJH36

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag N5878_RS11025 Protein ID WP_003112528.1
Coordinates 2345097..2345852 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag N5878_RS11030 Protein ID WP_003086329.1
Coordinates 2345987..2346355 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5878_RS11015 (N5878_11015) 2340270..2342813 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
N5878_RS11020 (N5878_11020) 2342968..2344329 - 1362 WP_073647918.1 DNA recombination protein RmuC -
N5878_RS11025 (N5878_11025) 2345097..2345852 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
N5878_RS11030 (N5878_11030) 2345987..2346355 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
N5878_RS11035 (N5878_11035) 2346428..2347714 - 1287 WP_023083139.1 FAD-binding oxidoreductase -
N5878_RS11040 (N5878_11040) 2347770..2349359 - 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
N5878_RS11045 (N5878_11045) 2349438..2349914 + 477 WP_003112531.1 hypothetical protein -
N5878_RS11050 (N5878_11050) 2349917..2350192 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T258511 WP_003112528.1 NZ_CP104590:c2345852-2345097 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT258511 WP_003086329.1 NZ_CP104590:c2346355-2345987 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References