Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4877912..4879170 Replicon chromosome
Accession NZ_CP104588
Organism Pseudomonas aeruginosa strain WTJH32

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag N5879_RS22700 Protein ID WP_003112528.1
Coordinates 4877912..4878667 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag N5879_RS22705 Protein ID WP_003086329.1
Coordinates 4878802..4879170 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5879_RS22690 (N5879_22690) 4873085..4875628 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
N5879_RS22695 (N5879_22695) 4875783..4877144 - 1362 WP_073647918.1 DNA recombination protein RmuC -
N5879_RS22700 (N5879_22700) 4877912..4878667 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
N5879_RS22705 (N5879_22705) 4878802..4879170 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
N5879_RS22710 (N5879_22710) 4879243..4880529 - 1287 WP_023083139.1 FAD-binding oxidoreductase -
N5879_RS22715 (N5879_22715) 4880585..4882174 - 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
N5879_RS22720 (N5879_22720) 4882253..4882729 + 477 WP_003112531.1 hypothetical protein -
N5879_RS22725 (N5879_22725) 4882732..4883007 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T258507 WP_003112528.1 NZ_CP104588:c4878667-4877912 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT258507 WP_003086329.1 NZ_CP104588:c4879170-4878802 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References