Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3949451..3950672 | Replicon | chromosome |
| Accession | NZ_CP104588 | ||
| Organism | Pseudomonas aeruginosa strain WTJH32 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | N5879_RS18335 | Protein ID | WP_003114949.1 |
| Coordinates | 3950094..3950672 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | N5879_RS18330 | Protein ID | WP_003088112.1 |
| Coordinates | 3949451..3950005 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N5879_RS18305 (N5879_18305) | 3945019..3945570 | + | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
| N5879_RS18310 (N5879_18310) | 3945567..3945965 | - | 399 | WP_023082958.1 | NADH-quinone oxidoreductase subunit A | - |
| N5879_RS18315 (N5879_18315) | 3945978..3946301 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| N5879_RS18320 (N5879_18320) | 3946632..3947093 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| N5879_RS18325 (N5879_18325) | 3947098..3949293 | + | 2196 | WP_023082959.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| N5879_RS18330 (N5879_18330) | 3949451..3950005 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| N5879_RS18335 (N5879_18335) | 3950094..3950672 | + | 579 | WP_003114949.1 | HD domain-containing protein | Toxin |
| N5879_RS18340 (N5879_18340) | 3950780..3951967 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| N5879_RS18345 (N5879_18345) | 3951957..3954128 | - | 2172 | WP_003088105.1 | type I secretion system permease/ATPase | - |
| N5879_RS18350 (N5879_18350) | 3954118..3955395 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21897.75 Da Isoelectric Point: 5.3655
>T258506 WP_003114949.1 NZ_CP104588:3950094-3950672 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT258506 WP_003088112.1 NZ_CP104588:3949451-3950005 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|