Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1646375..1648070 Replicon chromosome
Accession NZ_CP104588
Organism Pseudomonas aeruginosa strain WTJH32

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag N5879_RS07585 Protein ID WP_003112901.1
Coordinates 1646375..1647244 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag N5879_RS07590 Protein ID WP_003112902.1
Coordinates 1647237..1648070 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5879_RS07560 (N5879_07560) 1642383..1643234 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
N5879_RS07565 (N5879_07565) 1643275..1644282 + 1008 WP_023083382.1 ABC transporter substrate-binding protein -
N5879_RS07570 (N5879_07570) 1644279..1645055 + 777 WP_003112898.1 ABC transporter permease -
N5879_RS07575 (N5879_07575) 1645061..1645822 + 762 WP_023083383.1 SDR family oxidoreductase -
N5879_RS07580 (N5879_07580) 1645836..1646366 + 531 WP_003112900.1 cupin domain-containing protein -
N5879_RS07585 (N5879_07585) 1646375..1647244 + 870 WP_003112901.1 alpha/beta hydrolase Toxin
N5879_RS07590 (N5879_07590) 1647237..1648070 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
N5879_RS07595 (N5879_07595) 1648057..1648854 + 798 WP_003112903.1 SDR family oxidoreductase -
N5879_RS07600 (N5879_07600) 1648847..1650529 + 1683 WP_003130114.1 thiamine pyrophosphate-binding protein -
N5879_RS07605 (N5879_07605) 1650540..1651343 + 804 WP_003130116.1 aspartate dehydrogenase -
N5879_RS07610 (N5879_07610) 1651355..1652839 + 1485 WP_003453562.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T258503 WP_003112901.1 NZ_CP104588:1646375-1647244 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT258503 WP_003112902.1 NZ_CP104588:1647237-1648070 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References