258501

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 386443..387136 Replicon plasmid pWTJH6
Accession NZ_CP104587
Organism Pseudomonas aeruginosa strain WTJH6

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag N5877_RS33795 Protein ID WP_003151133.1
Coordinates 386759..387136 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag N5877_RS33790 Protein ID WP_001172026.1
Coordinates 386443..386778 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5877_RS33755 (N5877_33760) 382116..382940 - 825 WP_038405176.1 Ig-like domain-containing protein -
N5877_RS33760 (N5877_33765) 383851..383952 - 102 Protein_432 prepilin-type N-terminal cleavage/methylation domain-containing protein -
N5877_RS33765 (N5877_33770) 384123..384830 + 708 WP_034036499.1 hypothetical protein -
N5877_RS33770 (N5877_33775) 384858..385280 - 423 WP_260890453.1 hypothetical protein -
N5877_RS33775 (N5877_33780) 385375..385746 - 372 WP_172691856.1 hypothetical protein -
N5877_RS33780 (N5877_33785) 385743..386069 - 327 WP_000091614.1 hypothetical protein -
N5877_RS33785 (N5877_33790) 386093..386428 - 336 WP_000741275.1 hypothetical protein -
N5877_RS33790 (N5877_33795) 386443..386778 - 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
N5877_RS33795 (N5877_33800) 386759..387136 - 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5877_RS33800 (N5877_33805) 387328..387930 + 603 WP_010465829.1 recombinase family protein -
N5877_RS33805 (N5877_33810) 387914..390943 + 3030 WP_010799689.1 Tn3 family transposase -
N5877_RS33810 (N5877_33815) 390900..391481 - 582 WP_260890468.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(6)-Id / aph(3'')-Ib / sul1 / qacE / ant(3'')-Ia / blaOXA-101 / blaVIM-24 - 1..426499 426499


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T258501 WP_003151133.1 NZ_CP104587:c387136-386759 [Pseudomonas aeruginosa]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT258501 WP_001172026.1 NZ_CP104587:c386778-386443 [Pseudomonas aeruginosa]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References