Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 292895..293811 | Replicon | plasmid pWTJH6 |
| Accession | NZ_CP104587 | ||
| Organism | Pseudomonas aeruginosa strain WTJH6 | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | A0A212BIN6 |
| Locus tag | N5877_RS33300 | Protein ID | WP_021018402.1 |
| Coordinates | 292895..293419 (-) | Length | 175 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | A0A2I0C738 |
| Locus tag | N5877_RS33305 | Protein ID | WP_010792483.1 |
| Coordinates | 293416..293811 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N5877_RS33280 (N5877_33280) | 288211..289356 | + | 1146 | WP_021018404.1 | glycerate kinase | - |
| N5877_RS33285 (N5877_33285) | 289778..289969 | - | 192 | WP_010792486.1 | hypothetical protein | - |
| N5877_RS33290 (N5877_33290) | 290347..291402 | + | 1056 | WP_021018403.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
| N5877_RS33295 (N5877_33295) | 291599..292849 | + | 1251 | WP_010792484.1 | TerD family protein | - |
| N5877_RS33300 (N5877_33300) | 292895..293419 | - | 525 | WP_021018402.1 | RES family NAD+ phosphorylase | Toxin |
| N5877_RS33305 (N5877_33305) | 293416..293811 | - | 396 | WP_010792483.1 | hypothetical protein | Antitoxin |
| N5877_RS33310 (N5877_33310) | 294021..295955 | - | 1935 | WP_021018401.1 | hypothetical protein | - |
| N5877_RS33315 (N5877_33315) | 296104..296385 | + | 282 | WP_010792481.1 | hypothetical protein | - |
| N5877_RS33320 (N5877_33320) | 297264..297788 | + | 525 | WP_010792479.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aph(6)-Id / aph(3'')-Ib / sul1 / qacE / ant(3'')-Ia / blaOXA-101 / blaVIM-24 | - | 1..426499 | 426499 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 175 a.a. Molecular weight: 19011.47 Da Isoelectric Point: 4.4540
>T258500 WP_021018402.1 NZ_CP104587:c293419-292895 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQGSAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIVGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQGSAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIVGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
Download Length: 525 bp
Antitoxin
Download Length: 132 a.a. Molecular weight: 14810.93 Da Isoelectric Point: 7.2048
>AT258500 WP_010792483.1 NZ_CP104587:c293811-293416 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
Download Length: 396 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A212BIN6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I0C738 |