Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 6190428..6191649 | Replicon | chromosome |
| Accession | NZ_CP104586 | ||
| Organism | Pseudomonas aeruginosa strain WTJH6 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | N5877_RS28955 | Protein ID | WP_003114949.1 |
| Coordinates | 6190428..6191006 (-) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | N5877_RS28960 | Protein ID | WP_003088112.1 |
| Coordinates | 6191095..6191649 (-) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N5877_RS28940 (N5877_28940) | 6185705..6186982 | + | 1278 | WP_019726104.1 | TolC family protein | - |
| N5877_RS28945 (N5877_28945) | 6186972..6189143 | + | 2172 | WP_031642042.1 | type I secretion system permease/ATPase | - |
| N5877_RS28950 (N5877_28950) | 6189133..6190320 | + | 1188 | WP_019726106.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| N5877_RS28955 (N5877_28955) | 6190428..6191006 | - | 579 | WP_003114949.1 | HD domain-containing protein | Toxin |
| N5877_RS28960 (N5877_28960) | 6191095..6191649 | - | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| N5877_RS28965 (N5877_28965) | 6191807..6194002 | - | 2196 | WP_003450155.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| N5877_RS28970 (N5877_28970) | 6194007..6194468 | - | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| N5877_RS28975 (N5877_28975) | 6194799..6195122 | + | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| N5877_RS28980 (N5877_28980) | 6195135..6195533 | + | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| N5877_RS28985 (N5877_28985) | 6195530..6196081 | - | 552 | WP_003132721.1 | XRE family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21897.75 Da Isoelectric Point: 5.3655
>T258499 WP_003114949.1 NZ_CP104586:c6191006-6190428 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT258499 WP_003088112.1 NZ_CP104586:c6191649-6191095 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|