Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5166760..5168018 Replicon chromosome
Accession NZ_CP104586
Organism Pseudomonas aeruginosa strain WTJH6

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag N5877_RS23985 Protein ID WP_019725936.1
Coordinates 5167263..5168018 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag N5877_RS23980 Protein ID WP_003086329.1
Coordinates 5166760..5167128 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5877_RS23960 (N5877_23960) 5162923..5163198 + 276 WP_010792073.1 zinc ribbon domain-containing protein -
N5877_RS23965 (N5877_23965) 5163201..5163677 - 477 WP_019725934.1 hypothetical protein -
N5877_RS23970 (N5877_23970) 5163756..5165345 + 1590 WP_019725935.1 aldehyde dehydrogenase family protein -
N5877_RS23975 (N5877_23975) 5165401..5166687 + 1287 WP_003163134.1 FAD-binding oxidoreductase -
N5877_RS23980 (N5877_23980) 5166760..5167128 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
N5877_RS23985 (N5877_23985) 5167263..5168018 + 756 WP_019725936.1 RES family NAD+ phosphorylase Toxin
N5877_RS23990 (N5877_23990) 5168787..5170148 + 1362 WP_003081943.1 DNA recombination protein RmuC -
N5877_RS23995 (N5877_23995) 5170303..5172846 - 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28192.33 Da        Isoelectric Point: 8.0554

>T258498 WP_019725936.1 NZ_CP104586:5167263-5168018 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSGHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT258498 WP_003086329.1 NZ_CP104586:5166760-5167128 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References