258496

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4827136..4827744 Replicon chromosome
Accession NZ_CP104586
Organism Pseudomonas aeruginosa strain WTJH6

Toxin (Protein)


Gene name PfiT Uniprot ID -
Locus tag N5877_RS22330 Protein ID WP_016263850.1
Coordinates 4827397..4827744 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag N5877_RS22325 Protein ID WP_003114155.1
Coordinates 4827136..4827387 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5877_RS22305 (N5877_22305) 4822774..4823124 + 351 WP_019725830.1 DUF2523 family protein -
N5877_RS22310 (N5877_22310) 4823126..4824388 + 1263 WP_019725831.1 zonular occludens toxin domain-containing protein -
N5877_RS22315 (N5877_22315) 4824647..4825939 + 1293 WP_003115206.1 hypothetical protein -
N5877_RS22320 (N5877_22320) 4825939..4826922 + 984 WP_124166874.1 tyrosine-type recombinase/integrase -
N5877_RS22325 (N5877_22325) 4827136..4827387 + 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N5877_RS22330 (N5877_22330) 4827397..4827744 + 348 WP_016263850.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5877_RS22340 (N5877_22340) 4828071..4828973 - 903 WP_003123042.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
N5877_RS22345 (N5877_22345) 4829425..4830162 - 738 WP_003114158.1 murein L,D-transpeptidase catalytic domain family protein -
N5877_RS22350 (N5877_22350) 4830242..4831285 - 1044 WP_003098363.1 L,D-transpeptidase -
N5877_RS22355 (N5877_22355) 4831421..4832113 - 693 WP_003098362.1 16S rRNA pseudouridine(516) synthase -
N5877_RS22360 (N5877_22360) 4832113..4832385 - 273 WP_019725834.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4813210..4827744 14534


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13046.85 Da        Isoelectric Point: 4.4212

>T258496 WP_016263850.1 NZ_CP104586:4827397-4827744 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLVPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT258496 WP_003114155.1 NZ_CP104586:4827136-4827387 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References