Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 3016647..3017152 Replicon chromosome
Accession NZ_CP104586
Organism Pseudomonas aeruginosa strain WTJH6

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag N5877_RS13980 Protein ID WP_003083773.1
Coordinates 3016871..3017152 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag N5877_RS13975 Protein ID WP_003083775.1
Coordinates 3016647..3016874 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5877_RS13950 (N5877_13950) 3011665..3013158 + 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
N5877_RS13955 (N5877_13955) 3013327..3014754 + 1428 WP_003083784.1 GABA permease -
N5877_RS13960 (N5877_13960) 3014836..3015177 - 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
N5877_RS13965 (N5877_13965) 3015250..3015750 - 501 WP_003112629.1 LEA type 2 family protein -
N5877_RS13970 (N5877_13970) 3015851..3016471 + 621 WP_009314940.1 hypothetical protein -
N5877_RS13975 (N5877_13975) 3016647..3016874 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
N5877_RS13980 (N5877_13980) 3016871..3017152 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
N5877_RS13985 (N5877_13985) 3017452..3018360 + 909 WP_003083769.1 LysR family transcriptional regulator -
N5877_RS13990 (N5877_13990) 3018392..3018802 - 411 WP_003101225.1 aegerolysin family protein -
N5877_RS13995 (N5877_13995) 3018982..3019716 - 735 WP_003117208.1 GntR family transcriptional regulator -
N5877_RS14000 (N5877_14000) 3019817..3020503 - 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
N5877_RS14005 (N5877_14005) 3020552..3021901 - 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T258493 WP_003083773.1 NZ_CP104586:3016871-3017152 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT258493 WP_003083775.1 NZ_CP104586:3016647-3016874 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References