Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1260862..1262370 Replicon chromosome
Accession NZ_CP104586
Organism Pseudomonas aeruginosa strain WTJH6

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag N5877_RS05820 Protein ID WP_003119682.1
Coordinates 1261783..1262370 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9HYX2
Locus tag N5877_RS05815 Protein ID WP_003115566.1
Coordinates 1260862..1261716 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5877_RS05800 (N5877_05800) 1256281..1256490 + 210 WP_003115568.1 cold-shock protein -
N5877_RS05805 (N5877_05805) 1256551..1258425 - 1875 WP_019726548.1 MFS transporter -
N5877_RS05810 (N5877_05810) 1258600..1260765 - 2166 WP_003091606.1 TonB-dependent receptor family protein -
N5877_RS05815 (N5877_05815) 1260862..1261716 - 855 WP_003115566.1 AraC family transcriptional regulator Antitoxin
N5877_RS05820 (N5877_05820) 1261783..1262370 - 588 WP_003119682.1 GNAT family protein Toxin
N5877_RS05825 (N5877_05825) 1262636..1266115 + 3480 WP_023123573.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T258492 WP_003119682.1 NZ_CP104586:c1262370-1261783 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31933.23 Da        Isoelectric Point: 7.3276

>AT258492 WP_003115566.1 NZ_CP104586:c1261716-1260862 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB Q9HYX2

References