Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4884358..4885616 Replicon chromosome
Accession NZ_CP104584
Organism Pseudomonas aeruginosa strain WTJH2

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag N5876_RS22750 Protein ID WP_003112528.1
Coordinates 4884358..4885113 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag N5876_RS22755 Protein ID WP_003086329.1
Coordinates 4885248..4885616 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5876_RS22740 (N5876_22740) 4879531..4882074 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
N5876_RS22745 (N5876_22745) 4882229..4883590 - 1362 WP_073647918.1 DNA recombination protein RmuC -
N5876_RS22750 (N5876_22750) 4884358..4885113 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
N5876_RS22755 (N5876_22755) 4885248..4885616 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
N5876_RS22760 (N5876_22760) 4885689..4886975 - 1287 WP_023083139.1 FAD-binding oxidoreductase -
N5876_RS22765 (N5876_22765) 4887031..4888620 - 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
N5876_RS22770 (N5876_22770) 4888699..4889175 + 477 WP_003112531.1 hypothetical protein -
N5876_RS22775 (N5876_22775) 4889178..4889453 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T258489 WP_003112528.1 NZ_CP104584:c4885113-4884358 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT258489 WP_003086329.1 NZ_CP104584:c4885616-4885248 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References