Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3955897..3957118 | Replicon | chromosome |
| Accession | NZ_CP104584 | ||
| Organism | Pseudomonas aeruginosa strain WTJH2 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | N5876_RS18385 | Protein ID | WP_003114949.1 |
| Coordinates | 3956540..3957118 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | N5876_RS18380 | Protein ID | WP_003088112.1 |
| Coordinates | 3955897..3956451 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N5876_RS18355 (N5876_18355) | 3951465..3952016 | + | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
| N5876_RS18360 (N5876_18360) | 3952013..3952411 | - | 399 | WP_023082958.1 | NADH-quinone oxidoreductase subunit A | - |
| N5876_RS18365 (N5876_18365) | 3952424..3952747 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| N5876_RS18370 (N5876_18370) | 3953078..3953539 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| N5876_RS18375 (N5876_18375) | 3953544..3955739 | + | 2196 | WP_023082959.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| N5876_RS18380 (N5876_18380) | 3955897..3956451 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| N5876_RS18385 (N5876_18385) | 3956540..3957118 | + | 579 | WP_003114949.1 | HD domain-containing protein | Toxin |
| N5876_RS18390 (N5876_18390) | 3957226..3958413 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| N5876_RS18395 (N5876_18395) | 3958403..3960574 | - | 2172 | WP_003088105.1 | type I secretion system permease/ATPase | - |
| N5876_RS18400 (N5876_18400) | 3960564..3961841 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21897.75 Da Isoelectric Point: 5.3655
>T258488 WP_003114949.1 NZ_CP104584:3956540-3957118 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT258488 WP_003088112.1 NZ_CP104584:3955897-3956451 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|