Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3955897..3957118 Replicon chromosome
Accession NZ_CP104584
Organism Pseudomonas aeruginosa strain WTJH2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N5876_RS18385 Protein ID WP_003114949.1
Coordinates 3956540..3957118 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag N5876_RS18380 Protein ID WP_003088112.1
Coordinates 3955897..3956451 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5876_RS18355 (N5876_18355) 3951465..3952016 + 552 WP_003102727.1 XRE family transcriptional regulator -
N5876_RS18360 (N5876_18360) 3952013..3952411 - 399 WP_023082958.1 NADH-quinone oxidoreductase subunit A -
N5876_RS18365 (N5876_18365) 3952424..3952747 - 324 WP_003102734.1 multidrug efflux SMR transporter -
N5876_RS18370 (N5876_18370) 3953078..3953539 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
N5876_RS18375 (N5876_18375) 3953544..3955739 + 2196 WP_023082959.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
N5876_RS18380 (N5876_18380) 3955897..3956451 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
N5876_RS18385 (N5876_18385) 3956540..3957118 + 579 WP_003114949.1 HD domain-containing protein Toxin
N5876_RS18390 (N5876_18390) 3957226..3958413 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
N5876_RS18395 (N5876_18395) 3958403..3960574 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
N5876_RS18400 (N5876_18400) 3960564..3961841 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T258488 WP_003114949.1 NZ_CP104584:3956540-3957118 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT258488 WP_003088112.1 NZ_CP104584:3955897-3956451 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References