258487

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2453073..2454115 Replicon chromosome
Accession NZ_CP104584
Organism Pseudomonas aeruginosa strain WTJH2

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag N5876_RS11440 Protein ID WP_003153636.1
Coordinates 2453540..2454115 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag N5876_RS11435 Protein ID WP_003050245.1
Coordinates 2453073..2453543 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5876_RS11400 (N5876_11400) 2448452..2449870 - 1419 WP_004350605.1 TIGR03752 family integrating conjugative element protein -
N5876_RS11405 (N5876_11405) 2449860..2450771 - 912 WP_004350604.1 TIGR03749 family integrating conjugative element protein -
N5876_RS11410 (N5876_11410) 2450768..2451460 - 693 WP_012614071.1 TIGR03746 family integrating conjugative element protein -
N5876_RS11415 (N5876_11415) 2451457..2451867 - 411 WP_003821108.1 TIGR03750 family conjugal transfer protein -
N5876_RS11420 (N5876_11420) 2451880..2452239 - 360 WP_003153634.1 TIGR03745 family integrating conjugative element membrane protein -
N5876_RS11425 (N5876_11425) 2452256..2452489 - 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
N5876_RS11430 (N5876_11430) 2452486..2452869 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
N5876_RS11435 (N5876_11435) 2453073..2453543 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
N5876_RS11440 (N5876_11440) 2453540..2454115 + 576 WP_003153636.1 PIN domain-containing protein Toxin
N5876_RS11445 (N5876_11445) 2454133..2455047 + 915 WP_003050256.1 AAA family ATPase -
N5876_RS11450 (N5876_11450) 2455044..2455514 + 471 WP_003153638.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
N5876_RS11455 (N5876_11455) 2455511..2456011 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
N5876_RS11460 (N5876_11460) 2456011..2456913 + 903 WP_003153640.1 CBASS oligonucleotide cyclase -
N5876_RS11465 (N5876_11465) 2456952..2457677 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2389701..2500230 110529


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T258487 WP_003153636.1 NZ_CP104584:2453540-2454115 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT258487 WP_003050245.1 NZ_CP104584:2453073-2453543 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References