Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /Acetyltransf_4(toxin) |
Location | 1911422..1912930 | Replicon | chromosome |
Accession | NZ_CP104584 | ||
Organism | Pseudomonas aeruginosa strain WTJH2 |
Toxin (Protein)
Gene name | - | Uniprot ID | Q9HYX1 |
Locus tag | N5876_RS08825 | Protein ID | WP_003119682.1 |
Coordinates | 1911422..1912009 (+) | Length | 196 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A0A5B3ABU1 |
Locus tag | N5876_RS08830 | Protein ID | WP_003119683.1 |
Coordinates | 1912076..1912930 (+) | Length | 285 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N5876_RS08820 (N5876_08820) | 1907677..1911156 | - | 3480 | WP_003117605.1 | PAS domain-containing hybrid sensor histidine kinase/response regulator | - |
N5876_RS08825 (N5876_08825) | 1911422..1912009 | + | 588 | WP_003119682.1 | GNAT family protein | Toxin |
N5876_RS08830 (N5876_08830) | 1912076..1912930 | + | 855 | WP_003119683.1 | AraC family transcriptional regulator | Antitoxin |
N5876_RS08835 (N5876_08835) | 1913027..1915192 | + | 2166 | WP_016852624.1 | TonB-dependent receptor family protein | - |
N5876_RS08840 (N5876_08840) | 1915367..1917241 | + | 1875 | WP_003117607.1 | MFS transporter | - |
N5876_RS08845 (N5876_08845) | 1917302..1917511 | - | 210 | WP_003115568.1 | cold-shock protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 196 a.a. Molecular weight: 21901.23 Da Isoelectric Point: 9.8676
>T258486 WP_003119682.1 NZ_CP104584:1911422-1912009 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG
Download Length: 588 bp
Antitoxin
Download Length: 285 a.a. Molecular weight: 31875.19 Da Isoelectric Point: 7.5295
>AT258486 WP_003119683.1 NZ_CP104584:1912076-1912930 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE
Download Length: 855 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 1YRE | |
PDB | 8GXJ |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5B3ABU1 |