Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1911422..1912930 Replicon chromosome
Accession NZ_CP104584
Organism Pseudomonas aeruginosa strain WTJH2

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag N5876_RS08825 Protein ID WP_003119682.1
Coordinates 1911422..1912009 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag N5876_RS08830 Protein ID WP_003119683.1
Coordinates 1912076..1912930 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5876_RS08820 (N5876_08820) 1907677..1911156 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
N5876_RS08825 (N5876_08825) 1911422..1912009 + 588 WP_003119682.1 GNAT family protein Toxin
N5876_RS08830 (N5876_08830) 1912076..1912930 + 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
N5876_RS08835 (N5876_08835) 1913027..1915192 + 2166 WP_016852624.1 TonB-dependent receptor family protein -
N5876_RS08840 (N5876_08840) 1915367..1917241 + 1875 WP_003117607.1 MFS transporter -
N5876_RS08845 (N5876_08845) 1917302..1917511 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T258486 WP_003119682.1 NZ_CP104584:1911422-1912009 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT258486 WP_003119683.1 NZ_CP104584:1912076-1912930 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References