Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
Location | 1646370..1648065 | Replicon | chromosome |
Accession | NZ_CP104584 | ||
Organism | Pseudomonas aeruginosa strain WTJH2 |
Toxin (Protein)
Gene name | doc | Uniprot ID | Q9HYA0 |
Locus tag | N5876_RS07585 | Protein ID | WP_003112901.1 |
Coordinates | 1646370..1647239 (+) | Length | 290 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | Q9HYA1 |
Locus tag | N5876_RS07590 | Protein ID | WP_003112902.1 |
Coordinates | 1647232..1648065 (+) | Length | 278 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N5876_RS07560 (N5876_07560) | 1642378..1643229 | + | 852 | WP_003130104.1 | ABC transporter ATP-binding protein | - |
N5876_RS07565 (N5876_07565) | 1643270..1644277 | + | 1008 | WP_023083382.1 | ABC transporter substrate-binding protein | - |
N5876_RS07570 (N5876_07570) | 1644274..1645050 | + | 777 | WP_003112898.1 | ABC transporter permease | - |
N5876_RS07575 (N5876_07575) | 1645056..1645817 | + | 762 | WP_023083383.1 | SDR family oxidoreductase | - |
N5876_RS07580 (N5876_07580) | 1645831..1646361 | + | 531 | WP_003112900.1 | cupin domain-containing protein | - |
N5876_RS07585 (N5876_07585) | 1646370..1647239 | + | 870 | WP_003112901.1 | alpha/beta hydrolase | Toxin |
N5876_RS07590 (N5876_07590) | 1647232..1648065 | + | 834 | WP_003112902.1 | IclR family transcriptional regulator | Antitoxin |
N5876_RS07595 (N5876_07595) | 1648052..1648849 | + | 798 | WP_003112903.1 | SDR family oxidoreductase | - |
N5876_RS07600 (N5876_07600) | 1648842..1650524 | + | 1683 | WP_003130114.1 | thiamine pyrophosphate-binding protein | - |
N5876_RS07605 (N5876_07605) | 1650535..1651338 | + | 804 | WP_003130116.1 | aspartate dehydrogenase | - |
N5876_RS07610 (N5876_07610) | 1651350..1652834 | + | 1485 | WP_003453562.1 | aldehyde dehydrogenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 30403.60 Da Isoelectric Point: 6.5894
>T258485 WP_003112901.1 NZ_CP104584:1646370-1647239 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
Download Length: 870 bp
Antitoxin
Download Length: 278 a.a. Molecular weight: 30877.26 Da Isoelectric Point: 5.7725
>AT258485 WP_003112902.1 NZ_CP104584:1647232-1648065 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
Download Length: 834 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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