Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3531292..3532883 Replicon chromosome
Accession NZ_CP104583
Organism Pseudomonas sp. GD03721

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N5O88_RS17080 Protein ID WP_279531116.1
Coordinates 3531558..3532883 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N5O88_RS17075 Protein ID WP_147811819.1
Coordinates 3531292..3531558 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O88_RS17030 (N5O88_17020) 3526607..3526762 + 156 WP_279531113.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
N5O88_RS17035 (N5O88_17025) 3526833..3527918 + 1086 WP_011913346.1 IS5-like element ISPst12 family transposase -
N5O88_RS17040 (N5O88_17030) 3528023..3528181 + 159 WP_279531114.1 hypothetical protein -
N5O88_RS17045 (N5O88_17035) 3528766..3529014 + 249 WP_147811817.1 hypothetical protein -
N5O88_RS17050 (N5O88_17040) 3529011..3529538 + 528 WP_279531115.1 DUF3987 domain-containing protein -
N5O88_RS17055 (N5O88_17045) 3529580..3529870 + 291 Protein_3349 IS21 family transposase -
N5O88_RS17060 (N5O88_17050) 3529931..3530251 + 321 Protein_3350 IS30 family transposase -
N5O88_RS17065 (N5O88_17055) 3530293..3530871 + 579 WP_147811818.1 plasmid pRiA4b ORF-3 family protein -
N5O88_RS17070 (N5O88_17060) 3530886..3531199 + 314 Protein_3352 transposase domain-containing protein -
N5O88_RS17075 (N5O88_17065) 3531292..3531558 - 267 WP_147811819.1 helix-turn-helix transcriptional regulator Antitoxin
N5O88_RS17080 (N5O88_17070) 3531558..3532883 - 1326 WP_279531116.1 HipA domain-containing protein Toxin
N5O88_RS17085 (N5O88_17075) 3533352..3533782 + 431 Protein_3355 LLM class flavin-dependent oxidoreductase -
N5O88_RS17090 (N5O88_17080) 3533838..3534146 - 309 WP_147811821.1 putative quinol monooxygenase -
N5O88_RS17095 (N5O88_17085) 3534231..3535238 - 1008 WP_279531117.1 zinc-binding alcohol dehydrogenase family protein -
N5O88_RS17100 (N5O88_17090) 3535348..3536238 + 891 WP_147811826.1 LysR family transcriptional regulator -
N5O88_RS17105 (N5O88_17095) 3536259..3536501 - 243 WP_279533226.1 hypothetical protein -
N5O88_RS17110 (N5O88_17100) 3536532..3537008 + 477 Protein_3360 TraI domain-containing protein -
N5O88_RS17115 (N5O88_17105) 3537002..3537448 + 447 Protein_3361 IS21 family transposase -
N5O88_RS17120 (N5O88_17110) 3537447..3537702 + 256 Protein_3362 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3336006..3539281 203275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-384)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49170.67 Da        Isoelectric Point: 4.9451

>T258483 WP_279531116.1 NZ_CP104583:c3532883-3531558 [Pseudomonas sp. GD03721]
MHNLTLQAYRDGQWRNAMELRFEQPEEGLGGACAYGYQQGYLVDSLESVGTRLNAAVSAAYPLGWDSWRDKKAPAFLFDI
LPSGAARRFLLKRLGGERPEGLNLDLYLLGRCTPAPIGNLRIKESVEAITGSPVLGFTRDEVISRDSQFLEYAYEQGAAI
GGATGAGGEAPKLLLTEDRHGALHPDAVLPDADAAQHWFVKFARNKASQTDQDILRSEYCFYRAVQQLGMDTVAAEGLAL
EEGNKPSLWMHRFDREISPTGVSRTAVESMYSLCGVTEAGSYMLHTHVLGNLVELWRAVGQEQQVGDLVFEYMRRDLLNQ
ILGNSDNHGRNTAILRCEQGVRLAPIYDLAPMVMDEEGVTRTTKWPKHIELAGEVNWRMACDEVAEWVDADELFQRLRLA
AQDFLALPDLLSAQGLPDSTMSHPRIALRNLQQRMFQWGLV

Download         Length: 1326 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9972.63 Da        Isoelectric Point: 10.9502

>AT258483 WP_147811819.1 NZ_CP104583:c3531558-3531292 [Pseudomonas sp. GD03721]
MDILERNRILNELQQQLASGEITIGGAVRRLRKEVTGLQQARFAQMCKLSLRALRQLELDESNPTVQTLNNVFNPFGMQV
GIVPKLPR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References