Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3534700..3536291 Replicon chromosome
Accession NZ_CP104582
Organism Pseudomonas sp. GD03919

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N5O87_RS17110 Protein ID WP_279531116.1
Coordinates 3534966..3536291 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N5O87_RS17105 Protein ID WP_147811819.1
Coordinates 3534700..3534966 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O87_RS17060 (N5O87_17050) 3530015..3530170 + 156 WP_279531113.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
N5O87_RS17065 (N5O87_17055) 3530241..3531326 + 1086 WP_011913346.1 IS5-like element ISPst12 family transposase -
N5O87_RS17070 (N5O87_17060) 3531431..3531589 + 159 WP_279531114.1 hypothetical protein -
N5O87_RS17075 (N5O87_17065) 3532174..3532422 + 249 WP_147811817.1 hypothetical protein -
N5O87_RS17080 (N5O87_17070) 3532419..3532946 + 528 WP_279531115.1 DUF3987 domain-containing protein -
N5O87_RS17085 (N5O87_17075) 3532988..3533278 + 291 Protein_3355 IS21 family transposase -
N5O87_RS17090 (N5O87_17080) 3533339..3533659 + 321 Protein_3356 IS30 family transposase -
N5O87_RS17095 (N5O87_17085) 3533701..3534279 + 579 WP_147811818.1 plasmid pRiA4b ORF-3 family protein -
N5O87_RS17100 (N5O87_17090) 3534294..3534607 + 314 Protein_3358 transposase domain-containing protein -
N5O87_RS17105 (N5O87_17095) 3534700..3534966 - 267 WP_147811819.1 helix-turn-helix transcriptional regulator Antitoxin
N5O87_RS17110 (N5O87_17100) 3534966..3536291 - 1326 WP_279531116.1 HipA domain-containing protein Toxin
N5O87_RS17115 (N5O87_17105) 3536760..3537190 + 431 Protein_3361 LLM class flavin-dependent oxidoreductase -
N5O87_RS17120 (N5O87_17110) 3537246..3537554 - 309 WP_147811821.1 putative quinol monooxygenase -
N5O87_RS17125 (N5O87_17115) 3537639..3538646 - 1008 WP_279531117.1 zinc-binding alcohol dehydrogenase family protein -
N5O87_RS17130 (N5O87_17120) 3538756..3539646 + 891 WP_147811826.1 LysR family transcriptional regulator -
N5O87_RS17135 (N5O87_17125) 3539667..3539909 - 243 WP_279533226.1 hypothetical protein -
N5O87_RS17140 (N5O87_17130) 3539940..3540416 + 477 Protein_3366 TraI domain-containing protein -
N5O87_RS17145 (N5O87_17135) 3540410..3540856 + 447 Protein_3367 IS21 family transposase -
N5O87_RS17150 (N5O87_17140) 3540855..3541110 + 256 Protein_3368 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3337044..3542689 205645


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-384)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49170.67 Da        Isoelectric Point: 4.9451

>T258475 WP_279531116.1 NZ_CP104582:c3536291-3534966 [Pseudomonas sp. GD03919]
MHNLTLQAYRDGQWRNAMELRFEQPEEGLGGACAYGYQQGYLVDSLESVGTRLNAAVSAAYPLGWDSWRDKKAPAFLFDI
LPSGAARRFLLKRLGGERPEGLNLDLYLLGRCTPAPIGNLRIKESVEAITGSPVLGFTRDEVISRDSQFLEYAYEQGAAI
GGATGAGGEAPKLLLTEDRHGALHPDAVLPDADAAQHWFVKFARNKASQTDQDILRSEYCFYRAVQQLGMDTVAAEGLAL
EEGNKPSLWMHRFDREISPTGVSRTAVESMYSLCGVTEAGSYMLHTHVLGNLVELWRAVGQEQQVGDLVFEYMRRDLLNQ
ILGNSDNHGRNTAILRCEQGVRLAPIYDLAPMVMDEEGVTRTTKWPKHIELAGEVNWRMACDEVAEWVDADELFQRLRLA
AQDFLALPDLLSAQGLPDSTMSHPRIALRNLQQRMFQWGLV

Download         Length: 1326 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9972.63 Da        Isoelectric Point: 10.9502

>AT258475 WP_147811819.1 NZ_CP104582:c3534966-3534700 [Pseudomonas sp. GD03919]
MDILERNRILNELQQQLASGEITIGGAVRRLRKEVTGLQQARFAQMCKLSLRALRQLELDESNPTVQTLNNVFNPFGMQV
GIVPKLPR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References