258467

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 6405896..6407579 Replicon chromosome
Accession NZ_CP104581
Organism Delftia tsuruhatensis strain GD03927

Toxin (Protein)


Gene name doc Uniprot ID A0A1D8J415
Locus tag N5O86_RS29315 Protein ID WP_046240585.1
Coordinates 6406725..6407579 (-) Length 285 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A072T3J4
Locus tag N5O86_RS29310 Protein ID WP_016449819.1
Coordinates 6405896..6406702 (-) Length 269 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O86_RS29280 (N5O86_29330) 6401650..6402420 - 771 WP_012202888.1 SDR family oxidoreductase -
N5O86_RS29285 (N5O86_29335) 6402975..6403250 + 276 WP_046989307.1 hypothetical protein -
N5O86_RS29290 (N5O86_29340) 6403514..6403861 + 348 WP_013804511.1 type II toxin-antitoxin system RelE/ParE family toxin -
N5O86_RS29295 (N5O86_29345) 6403858..6404166 + 309 WP_016449816.1 XRE family transcriptional regulator -
N5O86_RS29300 (N5O86_29350) 6404179..6404940 - 762 WP_013804513.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
N5O86_RS29305 (N5O86_29355) 6405044..6405841 - 798 WP_034363548.1 aspartate dehydrogenase -
N5O86_RS29310 (N5O86_29360) 6405896..6406702 - 807 WP_016449819.1 IclR family transcriptional regulator Antitoxin
N5O86_RS29315 (N5O86_29365) 6406725..6407579 - 855 WP_046240585.1 alpha/beta fold hydrolase Toxin
N5O86_RS29320 (N5O86_29370) 6407594..6408124 - 531 WP_016449821.1 cupin domain-containing protein -
N5O86_RS29325 (N5O86_29375) 6408324..6409520 - 1197 WP_209799286.1 MFS transporter -
N5O86_RS29330 (N5O86_29380) 6409543..6410427 - 885 WP_034363416.1 NAD(P)-dependent oxidoreductase -
N5O86_RS29335 (N5O86_29385) 6410564..6411154 - 591 WP_013804518.1 TetR/AcrR family transcriptional regulator -
N5O86_RS29340 (N5O86_29390) 6411236..6411727 - 492 WP_016449824.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(43-270)

Antitoxin

Transcription regulator IclR, C-terminal

(137-255)


Sequences

Toxin        


Download         Length: 285 a.a.        Molecular weight: 29682.02 Da        Isoelectric Point: 7.8450

>T258467 WP_046240585.1 NZ_CP104581:c6407579-6406725 [Delftia tsuruhatensis]
MTAQTLQRMEQRLQAQFPEHLIALPGGAQVAWREAGDTTSDFAVVMLHGISSGAASWMDVALALAPRTRVLAWDASGYGR
STPLTPAAPTGADYARVLEQSLQALGVRRCLLVGHSLGALMGTPWAVQAGAGRVQQLVLISPAGGYGAPGMGEQQAKVRQ
GRLAALQEKGIEGLAAAIDQRLVSPAAPEPVRQWVRWNTARLHAAGYAQAVELLCGSDLGQAAGRLAMPVEVWVGEHDVV
TPPAACAAWAARLGARYVTLAAAGHASVVEQPADVAQRLATLLT

Download         Length: 855 bp

Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29047.08 Da        Isoelectric Point: 5.3408

>AT258467 WP_016449819.1 NZ_CP104581:c6406702-6405896 [Delftia tsuruhatensis]
MSDTSETLSNDNDRYTVPALERGLRLLACFTPSQPVWSAPDLARTLALPRSTVFRMLTTLEGMGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQSLCDRLGFTTNLALLDGTSVVYVARIAPAGAFQGAVRVGSRLPAHATVLGRALLQDMDA
DQLRALFGGSELPQFSESTPRSVEQLLQLLQQDHERGYAMGEGFYEPGVSSIAAPVRDAQGRIVAGLGMAVAFTEIAPGR
MADWVEQVRAAADELAGHLRTQHPGFLR

Download         Length: 807 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8J415

Antitoxin

Source ID Structure
AlphaFold DB A0A072T3J4

References