Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
Location | 6405896..6407579 | Replicon | chromosome |
Accession | NZ_CP104581 | ||
Organism | Delftia tsuruhatensis strain GD03927 |
Toxin (Protein)
Gene name | doc | Uniprot ID | A0A1D8J415 |
Locus tag | N5O86_RS29315 | Protein ID | WP_046240585.1 |
Coordinates | 6406725..6407579 (-) | Length | 285 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | A0A072T3J4 |
Locus tag | N5O86_RS29310 | Protein ID | WP_016449819.1 |
Coordinates | 6405896..6406702 (-) | Length | 269 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N5O86_RS29280 (N5O86_29330) | 6401650..6402420 | - | 771 | WP_012202888.1 | SDR family oxidoreductase | - |
N5O86_RS29285 (N5O86_29335) | 6402975..6403250 | + | 276 | WP_046989307.1 | hypothetical protein | - |
N5O86_RS29290 (N5O86_29340) | 6403514..6403861 | + | 348 | WP_013804511.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
N5O86_RS29295 (N5O86_29345) | 6403858..6404166 | + | 309 | WP_016449816.1 | XRE family transcriptional regulator | - |
N5O86_RS29300 (N5O86_29350) | 6404179..6404940 | - | 762 | WP_013804513.1 | 5'-methylthioadenosine/adenosylhomocysteine nucleosidase | - |
N5O86_RS29305 (N5O86_29355) | 6405044..6405841 | - | 798 | WP_034363548.1 | aspartate dehydrogenase | - |
N5O86_RS29310 (N5O86_29360) | 6405896..6406702 | - | 807 | WP_016449819.1 | IclR family transcriptional regulator | Antitoxin |
N5O86_RS29315 (N5O86_29365) | 6406725..6407579 | - | 855 | WP_046240585.1 | alpha/beta fold hydrolase | Toxin |
N5O86_RS29320 (N5O86_29370) | 6407594..6408124 | - | 531 | WP_016449821.1 | cupin domain-containing protein | - |
N5O86_RS29325 (N5O86_29375) | 6408324..6409520 | - | 1197 | WP_209799286.1 | MFS transporter | - |
N5O86_RS29330 (N5O86_29380) | 6409543..6410427 | - | 885 | WP_034363416.1 | NAD(P)-dependent oxidoreductase | - |
N5O86_RS29335 (N5O86_29385) | 6410564..6411154 | - | 591 | WP_013804518.1 | TetR/AcrR family transcriptional regulator | - |
N5O86_RS29340 (N5O86_29390) | 6411236..6411727 | - | 492 | WP_016449824.1 | Lrp/AsnC family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 285 a.a. Molecular weight: 29682.02 Da Isoelectric Point: 7.8450
>T258467 WP_046240585.1 NZ_CP104581:c6407579-6406725 [Delftia tsuruhatensis]
MTAQTLQRMEQRLQAQFPEHLIALPGGAQVAWREAGDTTSDFAVVMLHGISSGAASWMDVALALAPRTRVLAWDASGYGR
STPLTPAAPTGADYARVLEQSLQALGVRRCLLVGHSLGALMGTPWAVQAGAGRVQQLVLISPAGGYGAPGMGEQQAKVRQ
GRLAALQEKGIEGLAAAIDQRLVSPAAPEPVRQWVRWNTARLHAAGYAQAVELLCGSDLGQAAGRLAMPVEVWVGEHDVV
TPPAACAAWAARLGARYVTLAAAGHASVVEQPADVAQRLATLLT
MTAQTLQRMEQRLQAQFPEHLIALPGGAQVAWREAGDTTSDFAVVMLHGISSGAASWMDVALALAPRTRVLAWDASGYGR
STPLTPAAPTGADYARVLEQSLQALGVRRCLLVGHSLGALMGTPWAVQAGAGRVQQLVLISPAGGYGAPGMGEQQAKVRQ
GRLAALQEKGIEGLAAAIDQRLVSPAAPEPVRQWVRWNTARLHAAGYAQAVELLCGSDLGQAAGRLAMPVEVWVGEHDVV
TPPAACAAWAARLGARYVTLAAAGHASVVEQPADVAQRLATLLT
Download Length: 855 bp
Antitoxin
Download Length: 269 a.a. Molecular weight: 29047.08 Da Isoelectric Point: 5.3408
>AT258467 WP_016449819.1 NZ_CP104581:c6406702-6405896 [Delftia tsuruhatensis]
MSDTSETLSNDNDRYTVPALERGLRLLACFTPSQPVWSAPDLARTLALPRSTVFRMLTTLEGMGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQSLCDRLGFTTNLALLDGTSVVYVARIAPAGAFQGAVRVGSRLPAHATVLGRALLQDMDA
DQLRALFGGSELPQFSESTPRSVEQLLQLLQQDHERGYAMGEGFYEPGVSSIAAPVRDAQGRIVAGLGMAVAFTEIAPGR
MADWVEQVRAAADELAGHLRTQHPGFLR
MSDTSETLSNDNDRYTVPALERGLRLLACFTPSQPVWSAPDLARTLALPRSTVFRMLTTLEGMGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQSLCDRLGFTTNLALLDGTSVVYVARIAPAGAFQGAVRVGSRLPAHATVLGRALLQDMDA
DQLRALFGGSELPQFSESTPRSVEQLLQLLQQDHERGYAMGEGFYEPGVSSIAAPVRDAQGRIVAGLGMAVAFTEIAPGR
MADWVEQVRAAADELAGHLRTQHPGFLR
Download Length: 807 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1D8J415 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A072T3J4 |