Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2560193..2560902 Replicon chromosome
Accession NZ_CP104581
Organism Delftia tsuruhatensis strain GD03927

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N5O86_RS11565 Protein ID WP_016453265.1
Coordinates 2560193..2560639 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1D8IU58
Locus tag N5O86_RS11570 Protein ID WP_016453264.1
Coordinates 2560636..2560902 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O86_RS11545 (N5O86_11565) 2555791..2557005 + 1215 WP_279494992.1 ABC transporter permease -
N5O86_RS11550 (N5O86_11570) 2557007..2558152 + 1146 WP_279494994.1 ABC transporter permease -
N5O86_RS11555 (N5O86_11575) 2558216..2558845 - 630 WP_279494996.1 DUF4124 domain-containing protein -
N5O86_RS11560 (N5O86_11580) 2558924..2560129 - 1206 WP_016448243.1 MFS transporter -
N5O86_RS11565 (N5O86_11585) 2560193..2560639 - 447 WP_016453265.1 type II toxin-antitoxin system VapC family toxin Toxin
N5O86_RS11570 (N5O86_11590) 2560636..2560902 - 267 WP_016453264.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
N5O86_RS11575 (N5O86_11595) 2560927..2561898 - 972 WP_046988493.1 LysR family transcriptional regulator -
N5O86_RS11580 (N5O86_11600) 2561975..2562859 + 885 WP_279494998.1 amidohydrolase family protein -
N5O86_RS11585 (N5O86_11605) 2562886..2563881 + 996 WP_016448238.1 tripartite tricarboxylate transporter substrate binding protein -
N5O86_RS11590 (N5O86_11610) 2563905..2565536 - 1632 WP_016448237.1 gamma-glutamyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-133)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15880.46 Da        Isoelectric Point: 8.1045

>T258465 WP_016453265.1 NZ_CP104581:c2560639-2560193 [Delftia tsuruhatensis]
MTRYLLDTNIASHIIKGDIPAVREQLVRVPMHQIAVSAVTQAELMYGVAKRGHPAGLSLRVTGFLARVEVLPWTAQVADA
YGHLRAACEATGITLASMDMMIAAHALLLQQQAAQAGERSVLVTRDRVFSRIPEPGLAIADWTTGPAG

Download         Length: 447 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.3846

>AT258465 WP_016453264.1 NZ_CP104581:c2560902-2560636 [Delftia tsuruhatensis]
VTQTAKLFTTGRSQAVRLPYEFRFEEKEVYIRRDPVTGDVILSRRPDSWQEFFALDATTDVPADFMDTADRAQPESGRDP
FADEGSAR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8IU58

References