258460

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2627485..2628527 Replicon chromosome
Accession NZ_CP104580
Organism Stutzerimonas stutzeri strain GD04120

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag N5O82_RS12595 Protein ID WP_003153636.1
Coordinates 2627952..2628527 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag N5O82_RS12590 Protein ID WP_003050245.1
Coordinates 2627485..2627955 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O82_RS12555 (N5O82_12550) 2622864..2624282 - 1419 WP_004350605.1 TIGR03752 family integrating conjugative element protein -
N5O82_RS12560 (N5O82_12555) 2624272..2625183 - 912 WP_004350604.1 TIGR03749 family integrating conjugative element protein -
N5O82_RS12565 (N5O82_12560) 2625180..2625872 - 693 WP_012614071.1 TIGR03746 family integrating conjugative element protein -
N5O82_RS12570 (N5O82_12565) 2625869..2626279 - 411 WP_003821108.1 TIGR03750 family conjugal transfer protein -
N5O82_RS12575 (N5O82_12570) 2626292..2626651 - 360 WP_003153634.1 TIGR03745 family integrating conjugative element membrane protein -
N5O82_RS12580 (N5O82_12575) 2626668..2626901 - 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
N5O82_RS12585 (N5O82_12580) 2626898..2627281 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
N5O82_RS12590 (N5O82_12585) 2627485..2627955 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
N5O82_RS12595 (N5O82_12590) 2627952..2628527 + 576 WP_003153636.1 PIN domain-containing protein Toxin
N5O82_RS12600 (N5O82_12595) 2628545..2629459 + 915 WP_003050256.1 AAA family ATPase -
N5O82_RS12605 (N5O82_12600) 2629456..2629926 + 471 WP_003153638.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
N5O82_RS12610 (N5O82_12605) 2629923..2630423 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
N5O82_RS12615 (N5O82_12610) 2630423..2631325 + 903 WP_003153640.1 CBASS oligonucleotide cyclase -
N5O82_RS12620 (N5O82_12615) 2631364..2632089 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2562997..2681833 118836


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T258460 WP_003153636.1 NZ_CP104580:2627952-2628527 [Stutzerimonas stutzeri]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT258460 WP_003050245.1 NZ_CP104580:2627485-2627955 [Stutzerimonas stutzeri]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References