Detailed information of TA system TA258447

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 3998741..4000206
• Replicon: chromosome
• Accession: NZ_CP104562
• Organism: Roseateles sp. BIM B-1768

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: -
• Locus tag: N4261_RS16585
• Protein ID: WP_261756391.1
• Coordinates: 3999343..4000206 (+)
• Length: 288 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: -
• Locus tag: N4261_RS16580
• Protein ID: WP_261756390.1
• Coordinates: 3998741..3999346 (+)
• Length: 202 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N4261_RS16570 (N4261_16590)	3995073..3997544	+	2472	WP_261756388.1	TonB-dependent receptor	-
N4261_RS16575 (N4261_16595)	3997992..3998381	+	390	WP_261756389.1	GFA family protein	-
N4261_RS16580 (N4261_16600)	3998741..3999346	+	606	WP_261756390.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
N4261_RS16585 (N4261_16605)	3999343..4000206	+	864	WP_261756391.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
N4261_RS16595 (N4261_16615)	4000927..4001589	-	663	WP_261760738.1	phosphoglycolate phosphatase	-
N4261_RS16600 (N4261_16620)	4001631..4002332	-	702	WP_261756392.1	bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG	-
N4261_RS16605 (N4261_16625)	4002580..4003173	-	594	WP_261760739.1	OmpA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (38-265)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (14-55)

Sequences

Toxin

Protein

• Length: 288 a.a.
• Molecular weight: 31298.00 Da
• Isoelectric Point: 6.5002

>T258447 WP_261756391.1 NZ_CP104562:3999343-4000206 [Roseateles sp. BIM B-1768]
MNLANPNVAASIRARLLNIAKAQGVDFNQVLVRFALERMLYRMTQSQHANRFLLKGALLFTLWYDMPHRATRDADLLGFG
ASDLPSMADTFRDIAAVAGHDGIAFDPASVTVEEIRKEAGYGGVRVSIAGELAKARCKTQIDVGFGDAVTPGPVESVYPV
LLDDLPAPRLRAYPTYTVIAEKLHAIALLGMTNSRLKDYFDLSVLLERETLDADLLTQAIKATFERRGMSVPDAVPMGLT
DDFANDASRQSLWLAFIKKNELAAEPLPGVVDRLRSALAPALNRAAS

Nucleotide

• Length: 864 bp

Antitoxin

Protein

• Length: 202 a.a.
• Molecular weight: 22149.70 Da
• Isoelectric Point: 9.7176

>AT258447 WP_261756390.1 NZ_CP104562:3998741-3999346 [Roseateles sp. BIM B-1768]
MLPDTHTQRVLGLAGQKGLLRASDLDAIGAPRIVLTRLTAAGLLERVGRGLYRLPAFQGSEHESLATVATKAPQAVFCLL
TALQFHEMTTQLPRQIWIAMPRGSHVPRLDYPPIKMVQFTGDAYTAGAEEVEGDGVKFRVYGVAKTVADCFKHRHKIGLD
VALEALKEARSRNKASVDDIWRFAQVCRVANVMRPYLESLG

Nucleotide

• Length: 606 bp