Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2176204..2176718 Replicon chromosome
Accession NZ_CP104559
Organism Staphylococcus aureus strain SA2107

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag N4T05_RS10925 Protein ID WP_000581795.1
Coordinates 2176204..2176413 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag N4T05_RS10930 Protein ID WP_000138930.1
Coordinates 2176425..2176718 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T05_RS10905 (2171711) 2171711..2173069 - 1359 WP_234739929.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
N4T05_RS10910 (2173084) 2173084..2174154 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
N4T05_RS10915 (2174472) 2174472..2175674 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
N4T05_RS10920 (2175939) 2175939..2176076 - 138 WP_000828354.1 Lmo0850 family protein -
N4T05_RS10925 (2176204) 2176204..2176413 - 210 WP_000581795.1 heavy metal-associated domain-containing protein Toxin
N4T05_RS10930 (2176425) 2176425..2176718 - 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
N4T05_RS10935 (2176884) 2176884..2178368 + 1485 WP_000571562.1 cardiolipin synthase -
N4T05_RS10940 (2178396) 2178396..2179043 + 648 WP_001187625.1 HD domain-containing protein -
N4T05_RS10945 (2179593) 2179593..2180465 - 873 WP_000725802.1 membrane protein insertase YidC -
N4T05_RS10950 (2180551) 2180551..2181192 - 642 WP_000483162.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T258443 WP_000581795.1 NZ_CP104559:c2176413-2176204 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT258443 WP_000138930.1 NZ_CP104559:c2176718-2176425 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References