258442

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2156460..2156989 Replicon chromosome
Accession NZ_CP104559
Organism Staphylococcus aureus strain SA2107

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag N4T05_RS10835 Protein ID WP_000621175.1
Coordinates 2156460..2156822 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag N4T05_RS10840 Protein ID WP_000948331.1
Coordinates 2156819..2156989 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T05_RS10815 (2153439) 2153439..2154209 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
N4T05_RS10820 (2154184) 2154184..2154663 - 480 WP_001190825.1 anti-sigma B factor RsbW -
N4T05_RS10825 (2154665) 2154665..2154991 - 327 WP_001052491.1 anti-sigma factor antagonist -
N4T05_RS10830 (2155110) 2155110..2156111 - 1002 WP_042744356.1 PP2C family protein-serine/threonine phosphatase -
N4T05_RS10835 (2156460) 2156460..2156822 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
N4T05_RS10840 (2156819) 2156819..2156989 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
N4T05_RS10845 (2157074) 2157074..2158222 - 1149 WP_001281140.1 alanine racemase -
N4T05_RS10850 (2158288) 2158288..2158647 - 360 WP_000581199.1 holo-ACP synthase -
N4T05_RS10855 (2158651) 2158651..2159142 - 492 WP_001205907.1 PH domain-containing protein -
N4T05_RS10860 (2159129) 2159129..2160712 - 1584 WP_001294637.1 PH domain-containing protein -
N4T05_RS10865 (2160705) 2160705..2161184 - 480 WP_001287077.1 hypothetical protein -
N4T05_RS10870 (2161392) 2161392..2161952 - 561 WP_001092406.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T258442 WP_000621175.1 NZ_CP104559:c2156822-2156460 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT258442 WP_000948331.1 NZ_CP104559:c2156989-2156819 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References