258439

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1903742..1904518 Replicon chromosome
Accession NZ_CP104559
Organism Staphylococcus aureus strain SA2107

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag N4T05_RS09190 Protein ID WP_000031109.1
Coordinates 1903742..1903894 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag N4T05_RS09195 Protein ID WP_001251224.1
Coordinates 1903919..1904518 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T05_RS09175 (1899548) 1899548..1900369 + 822 WP_000669377.1 RluA family pseudouridine synthase -
N4T05_RS09180 (1900826) 1900826..1902211 - 1386 WP_000116239.1 class II fumarate hydratase -
N4T05_RS09185 (1902407) 1902407..1902802 - 396 WP_000901019.1 hypothetical protein -
N4T05_RS09190 (1903742) 1903742..1903894 - 153 WP_000031109.1 SAS053 family protein Toxin
N4T05_RS09195 (1903919) 1903919..1904518 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
N4T05_RS09200 (1904677) 1904677..1905147 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
N4T05_RS09205 (1905152) 1905152..1906279 - 1128 WP_261722546.1 tRNA epoxyqueuosine(34) reductase QueG -
N4T05_RS09210 (1906430) 1906430..1907152 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
N4T05_RS09215 (1907145) 1907145..1908602 - 1458 WP_000649916.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5950.31 Da        Isoelectric Point: 3.9075

>T258439 WP_000031109.1 NZ_CP104559:c1903894-1903742 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT258439 WP_001251224.1 NZ_CP104559:c1904518-1903919 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References