258437

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 840918..841447 Replicon chromosome
Accession NZ_CP104559
Organism Staphylococcus aureus strain SA2107

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX6
Locus tag N4T05_RS04035 Protein ID WP_001103939.1
Coordinates 841130..841447 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID X5IY59
Locus tag N4T05_RS04030 Protein ID WP_001058494.1
Coordinates 840918..841127 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T05_RS03995 (837247) 837247..837711 + 465 WP_001085185.1 SsrA-binding protein SmpB -
N4T05_RS04005 (838274) 838274..839380 - 1107 WP_000149511.1 tyrosine-type recombinase/integrase -
N4T05_RS04010 (839370) 839370..840173 - 804 WP_000358990.1 helix-turn-helix transcriptional regulator -
N4T05_RS04015 (840310) 840310..840513 + 204 WP_001045296.1 transcriptional regulator -
N4T05_RS04020 (840549) 840549..840767 + 219 WP_000163544.1 helix-turn-helix transcriptional regulator -
N4T05_RS04025 (840779) 840779..840925 + 147 WP_000784885.1 hypothetical protein -
N4T05_RS04030 (840918) 840918..841127 + 210 WP_001058494.1 hypothetical protein Antitoxin
N4T05_RS04035 (841130) 841130..841447 + 318 WP_001103939.1 DUF1474 family protein Toxin
N4T05_RS04040 (841511) 841511..842380 + 870 WP_001002717.1 primase alpha helix C-terminal domain-containing protein -
N4T05_RS04045 (842397) 842397..843854 + 1458 WP_000390453.1 virulence-associated E family protein -
N4T05_RS04050 (844155) 844155..844517 + 363 WP_001039170.1 hypothetical protein -
N4T05_RS04055 (844519) 844519..844803 + 285 WP_000998185.1 hypothetical protein -
N4T05_RS04060 (844800) 844800..845441 + 642 WP_001019808.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sec / sell / vWbp 838274..879739 41465
- inside Prophage - sec / sell 838274..858383 20109


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12547.17 Da        Isoelectric Point: 5.0161

>T258437 WP_001103939.1 NZ_CP104559:841130-841447 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE

Download         Length: 318 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8268.31 Da        Isoelectric Point: 4.3718

>AT258437 WP_001058494.1 NZ_CP104559:840918-841127 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX6

Antitoxin

Source ID Structure
AlphaFold DB X5IY59

References