Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 864284..865050 Replicon chromosome
Accession NZ_CP104555
Organism Vibrio sp. J502

Toxin (Protein)


Gene name - Uniprot ID A0A290PTK1
Locus tag N5E84_RS19785 Protein ID WP_017045788.1
Coordinates 864553..865050 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A290Q6J3
Locus tag N5E84_RS19780 Protein ID WP_019283269.1
Coordinates 864284..864556 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5E84_RS19750 (N5E84_19750) 860164..860325 + 162 Protein_778 IS30 family transposase -
N5E84_RS19755 (N5E84_19755) 860361..860708 - 348 WP_019283292.1 SH3 domain-containing protein -
N5E84_RS19760 (N5E84_19760) 860859..861380 - 522 WP_019283291.1 GNAT family N-acetyltransferase -
N5E84_RS19765 (N5E84_19765) 861524..861974 - 451 Protein_781 GyrI-like domain-containing protein -
N5E84_RS19770 (N5E84_19770) 863115..863534 - 420 WP_069212067.1 hypothetical protein -
N5E84_RS19775 (N5E84_19775) 864083..864244 - 162 WP_019283270.1 DUF3265 domain-containing protein -
N5E84_RS19780 (N5E84_19780) 864284..864556 + 273 WP_019283269.1 DUF1778 domain-containing protein Antitoxin
N5E84_RS19785 (N5E84_19785) 864553..865050 + 498 WP_017045788.1 GNAT family N-acetyltransferase Toxin
N5E84_RS19790 (N5E84_19790) 865084..865203 - 120 Protein_786 DUF3265 domain-containing protein -
N5E84_RS19795 (N5E84_19795) 865207..866175 - 969 WP_081245536.1 IS30 family transposase -
N5E84_RS19800 (N5E84_19800) 866291..866668 - 378 WP_019283451.1 hypothetical protein -
N5E84_RS19805 (N5E84_19805) 866718..866828 - 111 Protein_789 DUF3265 domain-containing protein -
N5E84_RS19810 (N5E84_19810) 866825..867538 - 714 WP_019283452.1 Fic family protein -
N5E84_RS19815 (N5E84_19815) 869329..869844 - 516 WP_019283453.1 peptide deformylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 850134..914576 64442
- inside IScluster/Tn - - 865207..911384 46177
- inside Integron - - 837523..869844 32321


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18524.30 Da        Isoelectric Point: 9.2813

>T258431 WP_017045788.1 NZ_CP104555:864553-865050 [Vibrio sp. J502]
MMKTVLLDKDKHDRNRFNCGIDALNNYLKVMASQQAKKDNTRTFVLEDENNTSLIIGFYTLTMTPIDLKTLPDKLQKKHQ
SSTSGGLIARLAIDDSYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFKAFQDAENKLFITISDI
RASLG

Download         Length: 498 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9917.47 Da        Isoelectric Point: 9.8130

>AT258431 WP_019283269.1 NZ_CP104555:864284-864556 [Vibrio sp. J502]
MATTLPRITARVDVDTQNLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQTLKLSQTDAILLMEALDKPTTLNQKLKT
AAERYETRTQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A290PTK1

Antitoxin

Source ID Structure
AlphaFold DB A0A290Q6J3

References