258424

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1499..1973 Replicon plasmid punamed2
Accession NZ_CP104552
Organism Klebsiella pneumoniae strain K28074

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag N5911_RS26710 Protein ID WP_004197762.1
Coordinates 1707..1973 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag N5911_RS26705 Protein ID WP_000879771.1
Coordinates 1499..1723 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5911_RS26695 (N5911_26695) 104..613 + 510 WP_032433972.1 MbeB family mobilization protein -
N5911_RS26700 (N5911_26700) 620..832 + 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
N5911_RS26705 (N5911_26705) 1499..1723 + 225 WP_000879771.1 DUF6290 family protein Antitoxin
N5911_RS26710 (N5911_26710) 1707..1973 + 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5911_RS26715 (N5911_26715) 2043..2393 - 351 WP_004197756.1 hypothetical protein -
N5911_RS26720 (N5911_26720) 2459..3004 - 546 WP_023317533.1 hypothetical protein -
N5911_RS26725 (N5911_26725) 3030..3356 - 327 WP_050516389.1 hypothetical protein -
N5911_RS26730 (N5911_26730) 4512..4688 + 177 WP_004197757.1 hypothetical protein -
N5911_RS26735 (N5911_26735) 4678..5022 + 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
N5911_RS26740 (N5911_26740) 5204..5449 - 246 WP_032433971.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T258424 WP_004197762.1 NZ_CP104552:1707-1973 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT258424 WP_000879771.1 NZ_CP104552:1499-1723 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References