Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5316461..5317086 Replicon chromosome
Accession NZ_CP104551
Organism Klebsiella pneumoniae strain K28074

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag N5911_RS26330 Protein ID WP_002882817.1
Coordinates 5316461..5316844 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag N5911_RS26335 Protein ID WP_004150355.1
Coordinates 5316844..5317086 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5911_RS26315 (N5911_26315) 5313827..5314729 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
N5911_RS26320 (N5911_26320) 5314726..5315361 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
N5911_RS26325 (N5911_26325) 5315358..5316287 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
N5911_RS26330 (N5911_26330) 5316461..5316844 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
N5911_RS26335 (N5911_26335) 5316844..5317086 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
N5911_RS26340 (N5911_26340) 5317291..5318208 + 918 WP_002882812.1 alpha/beta hydrolase -
N5911_RS26345 (N5911_26345) 5318222..5319163 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
N5911_RS26350 (N5911_26350) 5319208..5319645 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
N5911_RS26355 (N5911_26355) 5319642..5320502 - 861 WP_002882807.1 virulence factor BrkB family protein -
N5911_RS26360 (N5911_26360) 5320496..5321095 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T258423 WP_002882817.1 NZ_CP104551:c5316844-5316461 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT258423 WP_004150355.1 NZ_CP104551:c5317086-5316844 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References