Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2589149..2590737 Replicon chromosome
Accession NZ_CP104551
Organism Klebsiella pneumoniae strain K28074

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag N5911_RS13110 Protein ID WP_004199851.1
Coordinates 2589415..2590737 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag N5911_RS13105 Protein ID WP_002904790.1
Coordinates 2589149..2589415 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5911_RS13080 (N5911_13080) 2584299..2585222 + 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -
N5911_RS13085 (N5911_13085) 2585203..2586357 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
N5911_RS13090 (N5911_13090) 2586703..2588082 + 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
N5911_RS13095 (N5911_13095) 2588060..2588560 + 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
N5911_RS13100 (N5911_13100) 2588557..2588883 + 327 WP_002904788.1 hydroxyisourate hydrolase -
N5911_RS13105 (N5911_13105) 2589149..2589415 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N5911_RS13110 (N5911_13110) 2589415..2590737 + 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
N5911_RS13115 (N5911_13115) 2590754..2592046 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
N5911_RS13120 (N5911_13120) 2592179..2593183 - 1005 WP_004199852.1 fimbrial protein -
N5911_RS13125 (N5911_13125) 2593171..2595672 - 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T258414 WP_004199851.1 NZ_CP104551:2589415-2590737 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT258414 WP_002904790.1 NZ_CP104551:2589149-2589415 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References