Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 867199..867853 Replicon chromosome
Accession NZ_CP104551
Organism Klebsiella pneumoniae strain K28074

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag N5911_RS04385 Protein ID WP_004144731.1
Coordinates 867446..867853 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag N5911_RS04380 Protein ID WP_002916312.1
Coordinates 867199..867465 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5911_RS04355 (N5911_04355) 862355..863788 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
N5911_RS04360 (N5911_04360) 863907..864635 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
N5911_RS04365 (N5911_04365) 864685..864996 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
N5911_RS04370 (N5911_04370) 865160..865819 + 660 WP_002916317.1 hemolysin III family protein -
N5911_RS04375 (N5911_04375) 865970..866953 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
N5911_RS04380 (N5911_04380) 867199..867465 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
N5911_RS04385 (N5911_04385) 867446..867853 + 408 WP_004144731.1 protein YgfX Toxin
N5911_RS04390 (N5911_04390) 867860..868381 - 522 WP_002916308.1 flavodoxin FldB -
N5911_RS04395 (N5911_04395) 868482..869378 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
N5911_RS04400 (N5911_04400) 869401..870114 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N5911_RS04405 (N5911_04405) 870120..871853 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T258413 WP_004144731.1 NZ_CP104551:867446-867853 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT258413 WP_002916312.1 NZ_CP104551:867199-867465 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References