Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 721866..722521 Replicon chromosome
Accession NZ_CP104548
Organism Neisseria gonorrhoeae strain 10538

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NDL69_RS03865 Protein ID WP_003691083.1
Coordinates 722102..722521 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NDL69_RS03860 Protein ID WP_003688410.1
Coordinates 721866..722102 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDL69_RS03830 (NDL69_03835) 717000..717287 + 288 WP_003688407.1 hypothetical protein -
NDL69_RS03835 (NDL69_03840) 717359..718525 + 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
NDL69_RS03840 (NDL69_03845) 718536..719426 + 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
NDL69_RS03845 (NDL69_03850) 719809..720195 - 387 Protein_747 IS110 family transposase -
NDL69_RS03850 (NDL69_03855) 720434..720835 + 402 WP_020997339.1 helix-turn-helix domain-containing protein -
NDL69_RS03855 (NDL69_03860) 720840..721418 + 579 WP_003688041.1 IS3 family transposase -
NDL69_RS03860 (NDL69_03865) 721866..722102 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NDL69_RS03865 (NDL69_03870) 722102..722521 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NDL69_RS03870 (NDL69_03875) 722670..724124 - 1455 WP_003701282.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NDL69_RS03875 (NDL69_03880) 724121..724822 - 702 WP_003688414.1 lactate utilization protein C -
NDL69_RS03880 (NDL69_03885) 724819..725598 - 780 WP_003688416.1 (Fe-S)-binding protein -
NDL69_RS03885 (NDL69_03890) 725746..727287 + 1542 WP_003697015.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 719743..720216 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T258408 WP_003691083.1 NZ_CP104548:722102-722521 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT258408 WP_003688410.1 NZ_CP104548:721866-722102 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References