Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1405..1868 Replicon plasmid pJD1
Accession NZ_CP104547
Organism Neisseria gonorrhoeae strain 9035

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag NDL71_RS11790 Protein ID WP_003690225.1
Coordinates 1405..1683 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag NDL71_RS11795 Protein ID WP_003690223.1
Coordinates 1683..1868 (-) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDL71_RS11780 (NDL71_11790) 539..1126 + 588 WP_003692168.1 MbeB family mobilization protein -
NDL71_RS11785 (NDL71_11795) 1173..1427 + 255 WP_003690227.1 Cryptic plasmid protein A -
NDL71_RS11790 (NDL71_11800) 1405..1683 - 279 WP_003690225.1 endoribonuclease VapD Toxin
NDL71_RS11795 (NDL71_11805) 1683..1868 - 186 WP_003690223.1 DUF5397 family protein Antitoxin
NDL71_RS11800 (NDL71_11810) 1871..2116 - 246 WP_003690221.1 hypothetical protein -
NDL71_RS11805 (NDL71_11770) 2113..2355 - 243 WP_003690220.1 HTH domain-containing protein -
NDL71_RS11810 (NDL71_11775) 2359..3228 - 870 WP_003690219.1 replication initiation protein -
NDL71_RS11815 (NDL71_11780) 3614..3994 + 381 WP_014580441.1 MobC family plasmid mobilization relaxosome protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4153 4153


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T258407 WP_003690225.1 NZ_CP104547:c1683-1405 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT258407 WP_003690223.1 NZ_CP104547:c1868-1683 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References