Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1378789..1379444 Replicon chromosome
Accession NZ_CP104546
Organism Neisseria gonorrhoeae strain 9035

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NDL71_RS07515 Protein ID WP_003691083.1
Coordinates 1379025..1379444 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NDL71_RS07510 Protein ID WP_003688410.1
Coordinates 1378789..1379025 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDL71_RS07480 (NDL71_03855) 1373923..1374210 + 288 WP_003688407.1 hypothetical protein -
NDL71_RS07485 (NDL71_03860) 1374282..1375448 + 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
NDL71_RS07490 (NDL71_03865) 1375459..1376349 + 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
NDL71_RS07495 (NDL71_03870) 1376732..1377118 - 387 Protein_1442 IS110 family transposase -
NDL71_RS07500 (NDL71_03875) 1377357..1377758 + 402 WP_020997339.1 helix-turn-helix domain-containing protein -
NDL71_RS07505 (NDL71_03880) 1377763..1378341 + 579 WP_003688041.1 IS3 family transposase -
NDL71_RS07510 (NDL71_03885) 1378789..1379025 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NDL71_RS07515 (NDL71_03890) 1379025..1379444 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NDL71_RS07520 (NDL71_03895) 1379593..1381047 - 1455 WP_003701282.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NDL71_RS07525 (NDL71_03900) 1381044..1381745 - 702 WP_003688414.1 lactate utilization protein C -
NDL71_RS07530 (NDL71_03905) 1381742..1382521 - 780 WP_003688416.1 (Fe-S)-binding protein -
NDL71_RS07535 (NDL71_03910) 1382669..1384210 + 1542 WP_003697015.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1376666..1377139 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T258405 WP_003691083.1 NZ_CP104546:1379025-1379444 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT258405 WP_003688410.1 NZ_CP104546:1378789-1379025 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References