258390

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 93644..94179 Replicon plasmid p1
Accession NZ_CP104540
Organism Escherichia coli strain E6

Toxin (Protein)


Gene name relE Uniprot ID Q3YTD6
Locus tag N5O76_RS24095 Protein ID WP_000222766.1
Coordinates 93644..93931 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0VIP2
Locus tag N5O76_RS24100 Protein ID WP_001132900.1
Coordinates 93928..94179 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O76_RS24090 (92162) 92162..93375 + 1214 WP_191638310.1 IS3 family transposase -
N5O76_RS24095 (93644) 93644..93931 - 288 WP_000222766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5O76_RS24100 (93928) 93928..94179 - 252 WP_001132900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N5O76_RS24105 (95142) 95142..95999 - 858 WP_000774297.1 incFII family plasmid replication initiator RepA -
N5O76_RS24110 (95992) 95992..96474 - 483 WP_001273588.1 hypothetical protein -
N5O76_RS24115 (96467) 96467..96514 - 48 WP_229471593.1 hypothetical protein -
N5O76_RS24120 (96505) 96505..96756 + 252 WP_223195197.1 replication protein RepA -
N5O76_RS24125 (96773) 96773..97030 - 258 WP_000083845.1 replication regulatory protein RepA -
N5O76_RS24130 (97314) 97314..97463 - 150 WP_001312851.1 Hok/Gef family protein -
- (97507) 97507..97568 + 62 NuclAT_1 - -
- (97507) 97507..97568 + 62 NuclAT_1 - -
- (97507) 97507..97568 + 62 NuclAT_1 - -
- (97507) 97507..97568 + 62 NuclAT_1 - -
N5O76_RS24135 (97824) 97824..97898 - 75 Protein_95 endonuclease -
N5O76_RS24140 (98144) 98144..98356 - 213 WP_001299730.1 ANR family transcriptional regulator -
N5O76_RS24145 (98492) 98492..99052 - 561 WP_000139315.1 fertility inhibition protein FinO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iroB / iroC / iroD / iroE / iroN / vat / iutA / iucD / iucC / iucB / iucA 1..182456 182456


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11147.23 Da        Isoelectric Point: 10.5832

>T258390 WP_000222766.1 NZ_CP104540:c93931-93644 [Escherichia coli]
MTYTVKFRDDALKEWLKLDKTIQQQFVKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9211.41 Da        Isoelectric Point: 4.0780

>AT258390 WP_001132900.1 NZ_CP104540:c94179-93928 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDZ2

Antitoxin

Source ID Structure
AlphaFold DB V0VIP2

References