25839

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2723252..2723868 Replicon chromosome
Accession NC_016768
Organism Mycobacterium tuberculosis KZN 4207

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag TBSG_RS12910 Protein ID WP_003407593.1
Coordinates 2723252..2723569 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag TBSG_RS12915 Protein ID WP_003900349.1
Coordinates 2723566..2723868 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBSG_RS12880 2718261..2719289 - 1029 WP_003407612.1 glycosyltransferase family 2 protein -
TBSG_RS22370 2719559..2719783 + 225 WP_160522526.1 NUDIX domain-containing protein -
TBSG_RS12890 2719793..2720005 + 213 WP_003898900.1 dodecin family protein -
TBSG_RS12895 2720063..2720836 + 774 WP_003912632.1 class I SAM-dependent methyltransferase -
TBSG_RS12900 2720909..2722198 - 1290 WP_003407599.1 serine hydrolase -
TBSG_RS12905 2722251..2723255 - 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
TBSG_RS12910 2723252..2723569 - 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
TBSG_RS12915 2723566..2723868 - 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
TBSG_RS12920 2723882..2726134 - 2253 WP_003407587.1 methylmalonyl-CoA mutase -
TBSG_RS12925 2726135..2727982 - 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T25839 WP_003407593.1 NC_016768:c2723569-2723252 [Mycobacterium tuberculosis KZN 4207]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T25839 NC_016768:c2723569-2723252 [Mycobacterium tuberculosis KZN 4207]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT25839 WP_003900349.1 NC_016768:c2723868-2723566 [Mycobacterium tuberculosis KZN 4207]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT25839 NC_016768:c2723868-2723566 [Mycobacterium tuberculosis KZN 4207]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
AlphaFold DB G0TJ73

References